Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 1990  |  Volume : 32  |  Issue : 3  |  Page : 211-216

Factors Associated with the Course and Outcome of Schizophrenia a Multicentred Follow-up Study : Result of Five Year Follow-up

1 Professor and Head (Retired), Department of Psychiatry, Christian Medical College, Vellore, Co-ordinator and investigator, India
2 Professor and Senior Medical Superintendent (Retd.); and Director, WHO Field Centre, Mental Hospital, Agra, Consultant, India
3 Professor, Department of Psychiatry, Christian Medical College, Vellore, Co-investigator, India
4 Senior Research Officer, ICMR, India
5 Professor (Retd.), P-535, Raja Vasanta Roy Road, Calcutta, Consultant, India
6 Senior Research Officer ICMR, India
7 Additional Professor, Department of Psychiatry, Madras Medical College, Investigator, India
8 Reader in Biostatistics, Christian Medical College, Vellore, Statistical Co-ordinator, India
9 Professor and Superintendent, Institute of Medical Health (Retd.), Consultant, India
10 Proffessor and Head (Ex-) Department of Psychiatry, King George's Medical College, Lucknow, Investigator, India
11 Reader, Department of Psychiatry, King George's Medical College, Lucknow, Co-investigator, India

Correspondence Address:
A Verghese
Professor and Head (Retired), Department of Psychiatry, Christian Medical College, Vellore, Co-ordinator and investigator
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Source of Support: None, Conflict of Interest: None

PMID: 21927459

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This paper describes the results of a five year follow up study on factors associated with the course and outcome of schizophrenia conducted in 3 centers (Lucknow, Madras and Vellore) under the auspices of the Indian Council of Medical Research. 386 patients who satisfied well defined criteria of diagnosis and inclusion and exclusion criteria were studied. All patients were regularly followed up. 287 patients had complete follow up after 5 years. After 2 years, most of the active symptoms had subsided. At 5 year follow up, about 67% of the patients showed good outcome. Regular drug compliance, short duration of illness, absence of economic difficulties, absence of dangerous behaviour and delusions of presecution at intake; presence of agitation at intake; acute onset, absence of schizoid traits in personality, low level of education, rural background and lower age of onset were significantly related to good outcome. A combination of 8 factors could correctly predict the outcome in 80% of patients. The implications of the above findings are discussed.



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