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ARTICLE
Year : 1990  |  Volume : 32  |  Issue : 3  |  Page : 273-275

Tardive Dyskinesia : A Potential New Neurochemical


1 Assistant Professor, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560 029, India
2 Additional Professor, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560 029, India

Correspondence Address:
Chittaranjan Andrade
Assistant Professor, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560 029
India
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Source of Support: None, Conflict of Interest: None


PMID: 21927470

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Conventional neurochemical animal models of tardive dyskinesia are based upon the production of dopamine postsynaptic receptor supersensitivity by the chronic administration of neuroleptics. This study demonstrates that the same result is obtained by injecting Sprague-Dawley rats with a single ('high') dose of ipomorphine. It is hence suggested that apomorphine-induced time-dependant potentiation of dopaminepostsynaptic receptor response may be a more convenient neurochemical animal model of tardive dyskinesia; related theoretical and practical issues are discussed briefly, as also he methodological differences between the present study and an earlier report.



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