Indian Journal of PsychiatryIndian Journal of Psychiatry
Home | About us | Current Issue | Archives | Ahead of Print | Submission | Instructions | Subscribe | Advertise | Contact | Login 
    Users online: 13414 Small font sizeDefault font sizeIncrease font size Print this article Email this article Bookmark this page
Search Again
 Back
 Table of Contents
 
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Article Access Statistics
 Reader Comments
 Email Alert
 Add to My List
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed625    
    Printed24    
    Emailed0    
    PDF Downloaded47    
    Comments [Add]    

Recommend this journal

 
ARTICLE
Year : 1990  |  Volume : 32  |  Issue : 4  |  Page : 302-304

Single Electroconvulsive Shock and Dopamine Autoreceptors


1 Associate Professor in Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
2 Research Officer in Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India
3 Assistant Professor in Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India
4 Additional Professor in Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India

Correspondence Address:
B N Gangadhar
Associate Professor in Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 21927480

Rights and PermissionsRights and Permissions

Dopamine (DA) auto receptor down regulation has been suggested to mediate the therapeutic effect of antidepressant treatments including electroconvulsive therapy (ECT). Suggestion has also been made that a single ECT may have antidepressant potential via such a mechanism. The present study was therefore conducted to assess the effects ill a single electroconvulsive shock (ECS) on dopamine auto receptors in the rat brain. Using the low dose, Apomorphine-induccd by pomotilily behavioural paradigm, DA auto receptor function was studied one and eight days alter a single true ECS, and 8 days alter a single sham ECS. No significant difference was observed between the groups. The results suggest that single ECS exerts neither acute nor time-dependant DA auto receptor effects; however, the issue in certain aspects remains open for further study.



[PDF]*

        

Print this article         Email this article