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ARTICLE
Year : 1990  |  Volume : 32  |  Issue : 4  |  Page : 324-329

Platelet MAO Activity in Subgroups of Schizophrenia


1 Reader in Bio-Psychiatry, Department of Psychiatry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, India
2 Juniour Resident in Psychiatry, Department of Psychiatry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, India
3 Senior Research Officer, Centre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, India

Correspondence Address:
I Sharma
Reader in Bio-Psychiatry, Department of Psychiatry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005
India
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Source of Support: None, Conflict of Interest: None


PMID: 21927485

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Platelet MAO activity was estimated in 60 male drug free schizophrenics, 36 male drug free manics and 30 male normal healthy controls by Radio Isotopic Technique using 14 C Tryptamine Bisuccinate as substrate. There was no significant difference between the enzyme activity in the schizophrenic, manic and control groups. Platelet MAO activity in the disorganized catatonic and paranoid schizophrenics was significantly lower as compared to the enzyme activity in the manic and healthy control group. Platelet MAO activity appears to be related to subgroups of schizophrenia disorganized, catatonic and paranoid. Limitations and scope for future research have been outlined.



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