Indian Journal of PsychiatryIndian Journal of Psychiatry
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ARTICLE
Year : 1990  |  Volume : 32  |  Issue : 4  |  Page : 351-355

Post Dexamethasone Plasma Cortisol Levels as Indicator of Tricyclic Response in Major Depression


1 Lecturer in Psychiatry, Pandit Jawahar Lal Nehru Memorial Medical College, Raipur, M.P., India
2 Reader, Department of Psychiatry, King George's Medical College, Lucknow, India
3 Assistant Director, C.C.R.A.S. Unit, Department of pharmacology, King George's Medical College, Lucknow, India
4 Scientist, Industrial Toxicology Research Centre, Lucknow, India

Correspondence Address:
R Ghulam
Lecturer in Psychiatry, Pandit Jawahar Lal Nehru Memorial Medical College, Raipur, M.P.
India
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Source of Support: None, Conflict of Interest: None


PMID: 21927490

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Present study suggest that changes in response to the post dexamethasone plasma Cortisol levels in the patients of major depression receiveing anti depressants (Imipramine and Amitryptyline) might represent a laboratory marker of clinical progress. We estimated post dexamethasone plasma Cortisol levels weekly in thirty hospitalized patients during pro-treatment, post-treatment and drug .free post-treatment wash out period. In most of the cases normalization of the post dexamethasone Cortisol levels coincided with clinical improvement and failure to normalize was often associated with poorer clinical recovery. No significant difference was observed in the treatment response between imipramine and amitryptyline based on post dexamethasone plasma Cortisol levels.



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