Indian Journal of PsychiatryIndian Journal of Psychiatry
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ARTICLE
Year : 1993  |  Volume : 35  |  Issue : 1  |  Page : 54-57

Cognitive Functioning in Patients with Complex Absence Following Treatment with Sodium Valproate


1 Associate Professor of Clinical Psychology, National Institute of Mental Health and Neuro Sciences, Bangalore - 560 029, India
2 Associate Professor of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore - 560 029, India
3 Professor of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore - 560 029, India

Correspondence Address:
Shobini L Rao
Associate Professor of Clinical Psychology, National Institute of Mental Health and Neuro Sciences, Bangalore - 560 029
India
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Source of Support: None, Conflict of Interest: None


PMID: 21776171

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The association of sodium valproate with cognitive functions was studied in 29 patients with complex absence seizures. Seventeen patients were on monotherapy and twelve on polypharmacy with sodium valproate. Cognitive functions assessed were attention, speech, visuo-speciat perception, memory and intelligence. Behavioral disturbances were also assessed. Two assessments were made six months apart; in the first assessment, attention and speech were adequate, while memory, visuo-spatial perception, and behavioral functioning were impaired. Intelligence was lower in the polypharmacy group, while other functions were similar. In the second assessment, intelligence and visual memory improved in the monotherapy group, while no changes were present in the polypharmacy group.



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