Indian Journal of PsychiatryIndian Journal of Psychiatry
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ARTICLE
Year : 1994  |  Volume : 36  |  Issue : 1  |  Page : 30-32

Multifocal Leucoencephalopathy Presenting as Antidepressant Induced Mania


1 Senior Resident, Central Institute of Psychiatry, Kanke, Ranchi-6, India
2 Assistant Professor, Central Institute of Psychiatry, Kanke, Ranchi-6, India
3 Chief Medical Officer, Central Institute of Psychiatry, Kanke, Ranchi-6, India

Correspondence Address:
Saji S Damodaran
Senior Resident, Central Institute of Psychiatry, Kanke, Ranchi-6
India
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Source of Support: None, Conflict of Interest: None


PMID: 21743663

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A male patient presented with tricyclic induced hypomania after treatment for chronic depression. On follow up the patient deteriorated towards dementia with multifocal leucoencephalopathy. The possible role of brain lesions in the causation of affective syndromes and the neurobiological hypothesis of bipolar syndromes are discussed. The authors propose that chronic depression should be thoroughly investigated for a probable Axis III diagnosis.



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