Indian Journal of PsychiatryIndian Journal of Psychiatry
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ARTICLE
Year : 1997  |  Volume : 39  |  Issue : 1  |  Page : 41-48

CSF 5 - HIAA in Violent and Non-Violent Suicide Attempters


1 Associate Professor, Department of Psychiatry, K. G's Medical College, Lucknow, India
2 Ex-Senior Resident, Department of Psychiatry, K. G's Medical College, Lucknow, India
3 Assistant Professor, Department of Psychiatry, K. G's Medical College, Lucknow, India
4 Senior Statistician, Department of Psychiatry, K. G's Medical College, Lucknow, India
5 Senior Assistant, Director Pharmacology Division, Central Drug Research Institute, Lucknow, India

Correspondence Address:
J K Trivedi
Associate Professor, Department of Psychiatry, K. G's Medical College, Lucknow
India
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Source of Support: None, Conflict of Interest: None


PMID: 21584043

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Many studies have reported involvement of monoamine neurotransmission in suicide through measurement of serotonin and its main metabolite, 5-HIAA, in brain of suicide victims and in CSF of suicide attempters. 23 non-depressed non-psychotic suicide attempters and equal number of controls were selected, and all the subjects were screened on Cornell Medical Index. Suicide attempters were assessed on Risk-Rescue Rating Scale and were divided into non-violent suicide attempters (N= 12) and violent suicide attempters (N= II). CSF of all subjects was collected by lumbar puncture and CSF 5-HIAA was measured by high performance liquid chromatography with electro-chemical detector. Risk-rescue rating score was significantly higher in violent suicide attempters as compared to non-violent suicide attempters. Mean CSF- 5- HIAA was significantly lower in suicide attempters as compared to normal controls. Mean CSF 5-HIAA was significantly lower in violent suicide attempters as compared to non-violent suicide attempters.



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