Indian Journal of PsychiatryIndian Journal of Psychiatry
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ARTICLE
Year : 1998  |  Volume : 40  |  Issue : 1  |  Page : 60-66

Active Platelet 5-HT Uptake in Depressives Treated with Impramine and ECT


1 Associate Professor, Department Psychiatry, K.G.'s Medical College, Lucknow, India
2 Professor, Department Psychiatry, K.G.'s Medical College, Lucknow, India
3 Director, Industrial Toxicology Research Centre, Lucknow, India
4 Scientist, Industrial Toxicology Research Centre, Lucknow, India
5 Ex- Senior Resident, Department Psychiatry, K.G.'s Medical College, Lucknow, India

Correspondence Address:
P K Dalal
Associate Professor, Department Psychiatry, K.G.'s Medical College, Lucknow
India
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Source of Support: None, Conflict of Interest: None


PMID: 21494445

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Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.



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