Indian Journal of PsychiatryIndian Journal of Psychiatry
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ARTICLE
Year : 1999  |  Volume : 41  |  Issue : 2  |  Page : 96-99

Reemergence of Positive Symptoms of Schizophrenia During the Course of Treatment with Risperidone


1 Senior Resident, L.T.M. Medical College and L.T.M. General Hospital, Sion, Mumbat-400 022, India
2 Associate Professor, L.T.M. Medical College and L.T.M. General Hospital, Sion, Mumbat-400 022, India
3 Lecturer, L.T.M. Medical College and L.T.M. General Hospital, Sion, Mumbat-400 022, India
4 Junior Resident, L.T.M. Medical College and L.T.M. General Hospital, Sion, Mumbat-400 022, India

Correspondence Address:
Nilesh Shah
Associate Professor, L.T.M. Medical College and L.T.M. General Hospital, Sion, Mumbat-400 022
India
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Source of Support: None, Conflict of Interest: None


PMID: 21455369

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Thirty patients suffering from schizophrenia (diagnosed as per DSM-IV criteria), for more than 2 years and having predominant negative symptoms were started on risperidone (2-10 mg/day) and were followed up over a period of 16 weeks. The improvement was assessed using PANSS (Positive and Negative Syndrome Scale). During this 16 weeks follow up, it was interestingly noted that though there was a significant improvement in negative symptoms in all the patients, in 7 patients there was a reemergence of positive symptoms. Four patients had increase in rating on suspiciousness and hostility and two patients reported auditory hallucinations. One patient developed delusions and conceptual disorganization along with suspiciousness and hostility.



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