Indian Journal of PsychiatryIndian Journal of Psychiatry
Home | About us | Current Issue | Archives | Ahead of Print | Submission | Instructions | Subscribe | Advertise | Contact | Login 
    Users online: 697 Small font sizeDefault font sizeIncrease font size Print this article Email this article Bookmark this page
Search Again
 Back
 Table of Contents
 
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Article Access Statistics
 Reader Comments
 Email Alert
 Add to My List
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed544    
    Printed25    
    Emailed0    
    PDF Downloaded65    
    Comments [Add]    

Recommend this journal

 
ARTICLE
Year : 1999  |  Volume : 41  |  Issue : 3  |  Page : 228-235

Comparison of Therapeutic Efficacy of Ect and Imipramine : A Randomized Controlled Trial


1 Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore-560 029, India
2 Department of Biostatistics, National Institute of Mental Health and Neurosciences, Hosur Road Bangalore-560 029, India

Correspondence Address:
B N Gangadhar
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore-560 029
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 21455395

Rights and PermissionsRights and Permissions

Efficacy studies comparing ECT and tricyclics in depression have had methodological limitations. This study compared EC T and imipramine (IMN) prescribed as the first line of treatment in major depression, Drug-naive, consenting, DSM-IV major depression patients (n=28), were randomized to receive either bilateral ECTs or IMN (225 mg/d) for four weeks. Severity of depression was scored at twice weekly intervals. Subjective side effects were scored at second and fourth week. Patients had significant reductions in depression scores over time but there were no differences between the two treatment groups. The rate of antidepressant response did not significantly differ between the two groups. ECT group had significantly fewer side effects. IMN offered therapeutic response comparable to ECT without compromising on the speed of antidepressant response, but caused more side effects.



[PDF]*

        

Print this article         Email this article