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ARTICLE
Year : 1999  |  Volume : 41  |  Issue : 4  |  Page : 377-380

Primary Hypersomnia : Response to Fluoxetine and Methylphenidate


Additional Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India

Correspondence Address:
Chittaranjan Andrade
Additional Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029
India
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Source of Support: None, Conflict of Interest: None


PMID: 21430816

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Primary hypersomnia, a rare clinical syndrome, was diagnosed in a 14-year-old boy. The syndrome showed partial response to high dose fluoxetine therapy (120 mg/day) which recruited insomnia, an adverse effect of the drug, for therapeutic purposes. Response was enhanced with intermittent methylphenidate in association with a lower dose of fluoxetine. A possible pharmacokinetic interaction developed, comprising fluoxetine-induced augmentation of methylphenidate activity; such an interaction has not been previously reported.



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