Indian Journal of PsychiatryIndian Journal of Psychiatry
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ARTICLE
Year : 2000  |  Volume : 42  |  Issue : 3  |  Page : 291-294

Treatment of Obsessive Compulsive Symptoms in Schizophrenia with Fluoxetine


1 Senior Resident, Department of Psychiatry, Institute of Human Behaviour and Allied Sciences, Delhi, India
2 Consultant Psychiatrist, Department of Psychiatry, Institute of Human Behaviour and Allied Sciences, Delhi, India

Correspondence Address:
Vivek Agarwal
Room no. 7, Doctor's Hostel, Institute of Human Behaviour and Allied Sciences, Delhi-110095
India
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Source of Support: None, Conflict of Interest: None


PMID: 21407959

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Obsessive compulsive symptoms have been reported to occur in high proportion in schizophrenia. Presence of obsessive compulsive symptoms in schizophrenia has poor prognostic significance. Because of the antiobsessional effect of the fluoxetine, present study was undertaken as preliminary investigation in cases of schizophrenia with obsessive compulsive symptoms. We conducted an open trial of 12 weeks duration in which fluoxetine was added up to 80 mg to the maintenance neuroleptic medication of outpatients of schizophrenia with obsessive compulsive symptoms diagnosed by DSM-IV criteria. Five patients showed a significant reduction in scores of Positive and Negative Syndrome Scale, Yale Brown Obsessive Compulsive Scale and Clinical Global Impression Scale. Two patients did not show any response. Fluoxetine was well tolerated by all the patients. The positive findings of this preliminary investigation supports the further investigations of fluoxetine as potential treatment in the obsessive compulsive symptoms in schizophrenia.



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