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ARTICLE
Year : 2000  |  Volume : 42  |  Issue : 4  |  Page : 402-409

P 300 Event Related Potential in Depression


1 Resident, Department of Psychiatry, K G 's Medical College, Lucknow - 226 003, India
2 Professor, Department of Neurology, K G 's Medical College, Lucknow - 226 003, India
3 Professor, Department of Psychiatry, K G 's Medical College, Lucknow - 226 003, India
4 Statistician, Department of Psychiatry, K G 's Medical College, Lucknow - 226 003, India

Correspondence Address:
J. K Trivedi
Professor, Department of Psychiatry, K G 's Medical College, Lucknow - 226 003
India
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Source of Support: None, Conflict of Interest: None


PMID: 21407978

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P300 component of the event related potential (ERP) provides one neurophysiological index of cognitive dysfunction in depression. Forty subjects fulfilling DSM-III criteria for depression were compared to 40 age and sex matched normal controls. The P300 was recorded using the auditory odd-ball paradigm. Depressives had a significantly prolonged P300 latency and reduced P300 amplitude as compared to the controls. The P300 latency showed a significant positive correlation with age of the patient and severity of depression while P300 amplitude showed a significant negative correlation with age. The clinical subcategory of depression, duration of illness and sex did not show any relationship with P300 abnormality. Twelve out of 40 depressives (30%) had an abnormal P300. The mean Hamilton Rating Scale for Depression (HRSD) score was significantly high in those with an abnormal P300.



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