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ARTICLE
Year : 2002  |  Volume : 44  |  Issue : 2  |  Page : 173-176

Intravenous Valproate : A New Perspective in the Treatment of Manic Symptoms


1 Resident, Central Institute of Psychiatry, Kanke. Ranchi-834006, India
2 Senior Resident, Central Institute of Psychiatry, Kanke. Ranchi-834006, India
3 Chief Medical Officer, Central Institute of Psychiatry, Kanke. Ranchi-834006, India
4 Professor of Psychiatry & Director, Central Institute of Psychiatry, Kanke. Ranchi-834006, India

Correspondence Address:
Haque S Nizamie
Professor of Psychiatry & Director, Central Institute of Psychiatry, Kanke. Ranchi-834006
India
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Source of Support: None, Conflict of Interest: None


PMID: 21206565

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Over the last few years, the use of valproate in psychiatry has increased considerably. With the advent of oral loading dose strategy, its role in rapid treatment of acute mania has been demonstrated. The intravenous formulation of valproate, while retaining the rapidity of action of oral loading, also avoids some of the adverse effects of the oral preparation. Moreover, reports are pouring in that intravenous valproate loading may be more efficacious than oral valproate loading in the treatment of acute mania. We report two patients whose manic symptoms showed a dramatic response to intravenous valproate without adverse effects. The pharmacology of intravenous valproate and its clinical relevance to psychiatry are discussed.



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