Indian Journal of PsychiatryIndian Journal of Psychiatry
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BRIEF RESEARCH COMMUNICATION
Year : 2010  |  Volume : 52  |  Issue : 2  |  Page : 164-167

Effects of duration of untreated psychosis on long-term outcome of people hospitalized with first episode schizophrenia


1 Department of Psychiatry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada; and Lawson Health Research Institute, London, Ontario, Canada
2 LTMG Hospital, University of Mumbai, Sion, Mumbai-400 022, Maharashtra, India
3 Department of Psychology, University of Toronto, Toronto, ON, Canada
4 Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
5 Mental Health Foundation of India (PRERANA Charitable Trust) and Silver Mind Hospital, 209 Shivkripa Complex, Gokhale Road, Thane, Mumbai-400 602, Maharashtra, India
6 novaNAIT - Centre for Applied Research and Technology Transfer, The Northern Alberta Institute of Technology, 10504 Princess Elizabeth Avenue, Edmonton, Alberta, Canada T5G 3K4, Canada

Correspondence Address:
Amresh Shrivastava
Regional Mental Health Care, 467 Sunset Drive, St. Thomas, Ontario, Canada N5H 3V9
Canada
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5545.64583

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Duration of untreated psychosis (DUP) has emerged as a reliable predictor of outcome but continues to remain under scientific scrutiny. The present study examines the effect of differential periods of DUP on long-term outcome of first episode schizophrenia at Mumbai, India. This research was a prospective, 10-year follow-up naturalistic study. Hospitalized patients of first episode schizophrenia were selected and followed up. Results showed that the mean DUP was higher for a group which showed clinical recovery on Clinical Global Impression Scale [14.0 months (SD=8.0) in recovered and 10.8 months (SD=5.7) in non-recovered group (P=0.091)]. DUP was not found to be significantly associated with any of the end point parameters of good clinical or social outcome. Thus, this study found that DUP alone does not determine outcome status confirming the role of psychopathological heterogeneity.



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