|Year : 2010 | Volume
| Issue : 3 | Page : 236-242
Cannabis dependence: Effects of cannabis consumption on inter-regional cerebral metabolic relationships in an Indian population
Shubhangi R Parkar1, Seethalakshmi Ramanathan1, Narendra Nair2, Shefali A Batra1, Shilpa A Adarkar1, Anirudh G Pandit2, Purushottam Kund2, Nawab Singh Baghel2
1 Department of Psychiatry, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, India
2 Radiation Medicine Centre, BARC, Mumbai, India
Background: The effects of cannabis consumption on neurophysiological function have been a matter of considerable debate. With the legalization of medical marijuana, understanding the consequences of cannabis dependence has become extremely important.
Aim: We attempted to understand the influence of cannabis on cerebral glucose metabolism in certain predetermined regions of interest (ROIs). Furthermore, we also explored inter-regional metabolic relationships between ROIs forming the "addiction" and "cognitive dysmetria" circuit.
Materials and Me thods: 2-fluoro, 2-deoxy-glucose positron emission tomography (FDG PET) scans were carried out in 16 male patients (age: 25.3±10.38 years) with cannabis dependence, 8-12 hours after the last cannabis consumption. Resting glucose uptake in 14 pre-determined ROIs was compared with glucose uptake in 16 non-drug using volunteers (age: 29.2±8.39 years).
Results: The two groups differed in their lateral and medial temporal glucose uptakes by approximately 16-24%. The relationships between inter-regional glucose uptakes in the two circuits were compared using the Chow Test. Significant differences in inter-regional correlations in the medial temporo-frontal and parieto-thalamic were noted between the two groups.
Conclusion: The altered metabolic relationships among various brain regions can have potentially important implications for understanding cannabis dependence and cannabis-induced psychopathology.
Shubhangi R Parkar
Department of Psychiatry, Chief: Bombay Drug Deaddiction Center, G.S. Medical College and King Edward Memorial Hospital, Parel, Mumbai - 400 012
Source of Support: None, Conflict of Interest: None
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