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ORIGINAL ARTICLE
Year : 2011  |  Volume : 53  |  Issue : 1  |  Page : 25-29

Status of disulfiram in present day alcoholic deaddiction therapy


Department of Pharmacology, Fr. Muller Medical College, Mangalore - 575 002, India

Correspondence Address:
Elroy Saldanha
Blue heaven, 5-45, Krishnapura, Surathkal Post, Mangalore - 575 014
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5545.75557

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Aim: Assessment of safety and efficacy profile of disulfiram (DSM) in the alcoholic de-addiction regimen. Objectives: a . Assessment of Adverse Drug Reaction (ADR) profile; b. Evaluation of effectiveness of various de-addiction regimen; c. Defaulters and dropouts Patients and Methods: Fifty-one patients in a de-addiction center were investigated on 0 th , 30 th and 60 th day along with psychiatric evaluation, ADR surveillance was made. Statistical analysis was done thereafter. Results: 125 mg DSM given OD for 2 months. 76.5% patients had taken full course of treatment, 45% didn't complain of any ADR. Of ADR reported 27.4% had drowsiness, 21.4% tiredness, 7.8% skin manifestation. Conclusion: DSM is the main drug among naltrexone, acamprosate, nalmefene and other drugs used in alcoholic de-addiction. Relative and effectiveness is lost by the degree of dropouts and hence relapses. Low-dose DSM had decreased adverse effects with 76.5% patients taking the full course of treatment. DSM alters liver functions as there were significant changes in the lab parameters of SGPT(P=0.007), SGOT(P=0.001), GGT(P=<0.001) between first and third samples. Occurrence of ADR is not the cause of default; patients find it confusing to differentiate between the symptoms of alcohol withdrawal and those due to ADR of DSM.



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