Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 2012  |  Volume : 54  |  Issue : 1  |  Page : 88-90

Klinefelter's syndrome (mosaic) with chromosome 9 inv and schizophrenia

1 Department of Psychiatry, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
2 Biomedical Science Technology and Research, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
3 Department of Human Genetics, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India

Correspondence Address:
R Ponnudurai
24/3-B, T. T. K. Road, Chennai - 600 018
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5545.94655

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Klinefelter's syndrome is a sex chromosome abnormality with low androgen level. The varied manifestations of the mental symptoms in some of them, that are inexplicable based on their genotype alone, has fascinated the researchers. We present here a case of Klinefelter's syndrome having a karyotype of mos 47, XXY, and also inversion in 9 th chromosome, with schizophrenia. Despite the view that inv 9 is a normal variant, it is still worthwhile to explore whether it has any role in the etiology of schizophrenia especially when it occurs with other genotypic aberrations that are suspected to have relevance to psychiatric disorders including the Klinefelter's syndrome.



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