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CASE REPORT
Year : 2012  |  Volume : 54  |  Issue : 2  |  Page : 194-195

Antidepressant-induced mania in obsessive compulsive disorder


Department of Psychiatry, Sri. Ramachandra University, Chennai, Tamil Nadu, India

Correspondence Address:
Johann Philip
Department of Psychiatry, Sri Ramachandra Medical College, Sri Ramachandra University, Porur, Chennai - 600 116, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5545.99543

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Serotonin-reuptake inhibitors have come forth to become the mainstay of treatment in obsessive compulsive disorder (OCD), predominantly as a result of evidence from clinical psychopharmacological response studies. Comorbid psychiatric disorders frequent OCD patients, most often depression. Although selective serotonin reuptake inhibitors are effective in the treatment of both OCD and depressive disorder, all antidepressants are associated with treatment-emergent affective switch. We present a 48-year-old patient with OCD, on antidepressants, initially for OCD and later for depression as well. She switched to mania after 20 years of treatment, which responded to olanzapine and divalproex sodium.



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