Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 2014  |  Volume : 56  |  Issue : 1  |  Page : 76-78

Marchiafawa bignami disease possibly related to consumption of a locally brewed alcoholic beverage: Report of two cases

1 Department of Psychiatry, Jagjivan Ram Hospital, Mumbai, Maharashtra, India
2 BYL Nair Hospital and Topiwala National Medical College, Mumbai, Maharashtra, India

Correspondence Address:
Jagdeo P Rawat
11/6, Sky Scrapper Building, Western Railways Officers Flats, A. L. Nair Road, Mumbai Central, Mumbai - 400 008, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5545.124720

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Marchiafava Bignami disease is a rare toxic disease seen mostly in chronic alcoholics, resulting in progressive demyelination and necrosis of the corpus callosum. Initially it was thought to be specific to individuals in central Italy, consuming large amounts of Chianti red wine; however, alcoholic beverages worldwide are presently implicated. In our case series of two cases, locally made "illicit" liquor (Mahuwa Alcohol) could be the causative factor. In radiological point of view typically the corpus callosum is affected, with involvement of the body, genu, and splenium in order of occurrence. Occasionally the entire callosum may be also involved. Clinical presentation varies from case to case.



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