Indian Journal of PsychiatryIndian Journal of Psychiatry
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LETTERS TO EDITOR  
Year : 2019  |  Volume : 61  |  Issue : 4  |  Page : 424
Baclofen versus lorazepam for alcohol withdrawal


1 Department of Psychiatry, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
2 Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

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Date of Web Publication16-Jul-2019
 

How to cite this article:
Garag SS, Andrade C. Baclofen versus lorazepam for alcohol withdrawal. Indian J Psychiatry 2019;61:424

How to cite this URL:
Garag SS, Andrade C. Baclofen versus lorazepam for alcohol withdrawal. Indian J Psychiatry [serial online] 2019 [cited 2019 Aug 20];61:424. Available from: http://www.indianjpsychiatry.org/text.asp?2019/61/4/424/262792




Sir,

Gulati et al.[1] compared the efficacy of baclofen and lorazepam in 66 patients during uncomplicated alcohol withdrawal. They used an open-label, randomized Controlled study design. We believe that the study design was vitiated by two issues. One was the use of fixed drug dosing in the baclofen arm versus flexible drug dosing in the lorazepam arm; this discriminated against baclofen. The other was the use of rescue zolpidem in the baclofen arm only; this discriminated against lorazepam. Generalizations about the relative efficacies of baclofen and lorazepam are therefore problematic.

We also note that while about 45% of baclofen patients were reported to require rescue lorazepam, the average number of occasions of use of rescue medication by each patient was not stated. Other matters of concern are that Table 1 in their paper provides information on only 45 out of the 66 patients and that ANOVA was used to compare “ordinal” variables; did the authors mean continuous variables?

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There are no conflicts of interest.



 
   References Top

1.
Gulati P, Chavan BS, Sidana A. Comparative efficacy of baclofen and lorazepam in the treatment of alcohol withdrawal syndrome. Indian J Psychiatry 2019;61:60-4.  Back to cited text no. 1
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Correspondence Address:
Sagar S Garag
Department of Psychiatry, Karnataka Institute of Medical Sciences, Hubballi, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/psychiatry.IndianJPsychiatry_108_19

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