Indian Journal of PsychiatryIndian Journal of Psychiatry
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ORIGINAL ARTICLE
Year : 2019  |  Volume : 61  |  Issue : 6  |  Page : 618-622

A comparative study of temperamental, behavioral, and cognitive changes in thalassemia major, thalassemia minor, and normal population


1 Department of Psychiatry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India
2 Department of Psychiatry, College of Medicine and JNM Hospital, Kalyani, Nadia, West Bengal, India
3 Department of Pathology, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India
4 Department of Psychiatry, R G Kar Medical College and Hospital, Kolkata, West Bengal, India
5 Department of Pathology, ESI Hospital Post Graduate Institute of Medical Sciences and Research, Kolkata, West Bengal, India

Correspondence Address:
Dr. Arya Sen
Flat-5, 60 Selimpur Lane, Kolkata - 700 031, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/psychiatry.IndianJPsychiatry_459_18

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Background: Temperament in children and adolescents acts as a trait marker which can predict behavioral abnormalities. There was no systemic study in India which has compared the temperamental, behavioral and cognitive changes associated with this hemoglobinopathy among thalassemia major (TM) group. Materials and Methods: The specific objectives of this study were to find the clinicodemographic profile of individuals and parents, the behavioral, temperamental profile of children of beta TM and correlation of temperamental profile with number of blood transfusions, cognitive profile of children having beta TM, minor and age-matched control children and adolescents. Results: Child and adolescents having TM have more temperamental and behavioral problems (P < 0.001) and have more psychopathology in comparison to Tm group. Descriptive statistics of the groups and group comparison (ANOVA) shows statistically significant difference in Temperament Measurement Schedule (TMS) total, CPMS total, TMT A, TMT B, and Children's Depression Rating Scale (CDRS) scales (P = 0.000). Descriptive statistics and group comparison (Chi-square test) show significance in number of blood transfusions not with other parameters (P < 0.001). Comparison between TM (Case) and Tm (Control) (t-test) shows significance with only TMS total and CPMS scales, not in other scales. The correlation matrix showed significant correlation in-between all the parameters (blood transfusion, TMS, CPMS, TMT A, TMT B, and CDRS). Discussion: Those who have been diagnosed as TM have more behavioral and cognitive problems than their comparators. Youngsters receiving more blood transfusions due to their ailments scored higher in childhood depression rating scale. Conclusion: The temperamental, behavioural and cognitive profile are key determinants of both internalizing and externalizing symptoms and management plan can be guided accordingly as reflected in this study.



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