Year : 1993  |  Volume : 35  |  Issue : 3  |  Page : 179--180

BR - 16A does not Interfere with Alpha - 2 Noradrenergic and Dopamine Postsynaptic Receptor Functioning


Chittaranjan Andrade1, Jenniffer George2, Thangam Joseph3 
1 Associate Professor, Department of Psychopharmacology, NIMHANS, Bangalore - 560 029, India
2 Lecturer, Department of Pharmacology, St. John's Medical College, Bangalore, India
3 Professor and Head, Department of Pharmacology, St. John's Medical College, Bangalore, India

Correspondence Address:
Chittaranjan Andrade
Associate Professor, Department of Psychopharmacology, NIMHANS, Bangalore - 560 029
India

BR-16A is a herbal preparation with several putative psychotropic effects. Recent work has suggested that it facilities certain aspects of cognition and that it ameliorates ECT-induced amnesia in animal models. The present study sought to assess whether it affects noradrenergic and dopaminergic functioning in the central nervous system. Adult male Sprague-Dawley rats received BR-16A (200mg/kg) or vehicle for one month. The animals were subsequently challenged with clonidine (100 mg/kg I.P.), apomorphine (2mg/kg I.P.), or saline in a factorial design, and motility of the animals was immediately thereafter assessed using a small open field. BR-16A neither attenuated clonidine induced alpha-2 noradrenergic receptor-mediated hypomotility nor accentuated apomorphine-induced dopamine postsynaptic receptor-mediated hypermotility, suggesting that it does not interfere with alpha-2 noradrenergic and dopamine postsynaptic receptor functioning.


How to cite this article:
Andrade C, George J, Joseph T. BR - 16A does not Interfere with Alpha - 2 Noradrenergic and Dopamine Postsynaptic Receptor Functioning.Indian J Psychiatry 1993;35:179-180


How to cite this URL:
Andrade C, George J, Joseph T. BR - 16A does not Interfere with Alpha - 2 Noradrenergic and Dopamine Postsynaptic Receptor Functioning. Indian J Psychiatry [serial online] 1993 [cited 2020 Apr 4 ];35:179-180
Available from: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=1993;volume=35;issue=3;spage=179;epage=180;aulast=Andrade;type=0