Year : 1999  |  Volume : 41  |  Issue : 4  |  Page : 377--380

Primary Hypersomnia : Response to Fluoxetine and Methylphenidate


Chittaranjan Andrade 
 Additional Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India

Correspondence Address:
Chittaranjan Andrade
Additional Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029
India

Primary hypersomnia, a rare clinical syndrome, was diagnosed in a 14-year-old boy. The syndrome showed partial response to high dose fluoxetine therapy (120 mg/day) which recruited insomnia, an adverse effect of the drug, for therapeutic purposes. Response was enhanced with intermittent methylphenidate in association with a lower dose of fluoxetine. A possible pharmacokinetic interaction developed, comprising fluoxetine-induced augmentation of methylphenidate activity; such an interaction has not been previously reported.


How to cite this article:
Andrade C. Primary Hypersomnia : Response to Fluoxetine and Methylphenidate.Indian J Psychiatry 1999;41:377-380


How to cite this URL:
Andrade C. Primary Hypersomnia : Response to Fluoxetine and Methylphenidate. Indian J Psychiatry [serial online] 1999 [cited 2020 Sep 22 ];41:377-380
Available from: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=1999;volume=41;issue=4;spage=377;epage=380;aulast=Andrade;type=0