Year : 2002  |  Volume : 44  |  Issue : 2  |  Page : 173--176

Intravenous Valproate : A New Perspective in the Treatment of Manic Symptoms


Harpreet S Duggal1, K. Jagadheesan2, Subhash Gupta1, Soumya Basu1, Sayeed Akhtar3, Haque S Nizamie4 
1 Resident, Central Institute of Psychiatry, Kanke. Ranchi-834006, India
2 Senior Resident, Central Institute of Psychiatry, Kanke. Ranchi-834006, India
3 Chief Medical Officer, Central Institute of Psychiatry, Kanke. Ranchi-834006, India
4 Professor of Psychiatry & Director, Central Institute of Psychiatry, Kanke. Ranchi-834006, India

Correspondence Address:
Haque S Nizamie
Professor of Psychiatry & Director, Central Institute of Psychiatry, Kanke. Ranchi-834006
India

Over the last few years, the use of valproate in psychiatry has increased considerably. With the advent of oral loading dose strategy, its role in rapid treatment of acute mania has been demonstrated. The intravenous formulation of valproate, while retaining the rapidity of action of oral loading, also avoids some of the adverse effects of the oral preparation. Moreover, reports are pouring in that intravenous valproate loading may be more efficacious than oral valproate loading in the treatment of acute mania. We report two patients whose manic symptoms showed a dramatic response to intravenous valproate without adverse effects. The pharmacology of intravenous valproate and its clinical relevance to psychiatry are discussed.


How to cite this article:
Duggal H, Jagadheesan K, Gupta S, Basu S, Akhtar S, Nizamie HS. Intravenous Valproate : A New Perspective in the Treatment of Manic Symptoms.Indian J Psychiatry 2002;44:173-176


How to cite this URL:
Duggal H, Jagadheesan K, Gupta S, Basu S, Akhtar S, Nizamie HS. Intravenous Valproate : A New Perspective in the Treatment of Manic Symptoms. Indian J Psychiatry [serial online] 2002 [cited 2019 Sep 21 ];44:173-176
Available from: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2002;volume=44;issue=2;spage=173;epage=176;aulast=Duggal;type=0