Year : 2011  |  Volume : 53  |  Issue : 1  |  Page : 25--29

Status of disulfiram in present day alcoholic deaddiction therapy


Princy Louis Palatty, Elroy Saldanha 
 Department of Pharmacology, Fr. Muller Medical College, Mangalore - 575 002, India

Correspondence Address:
Elroy Saldanha
Blue heaven, 5-45, Krishnapura, Surathkal Post, Mangalore - 575 014
India

Aim: Assessment of safety and efficacy profile of disulfiram (DSM) in the alcoholic de-addiction regimen. Objectives: a . Assessment of Adverse Drug Reaction (ADR) profile; b. Evaluation of effectiveness of various de-addiction regimen; c. Defaulters and dropouts Patients and Methods: Fifty-one patients in a de-addiction center were investigated on 0 th , 30 th and 60 th day along with psychiatric evaluation, ADR surveillance was made. Statistical analysis was done thereafter. Results: 125 mg DSM given OD for 2 months. 76.5% patients had taken full course of treatment, 45% didn«SQ»t complain of any ADR. Of ADR reported 27.4% had drowsiness, 21.4% tiredness, 7.8% skin manifestation. Conclusion: DSM is the main drug among naltrexone, acamprosate, nalmefene and other drugs used in alcoholic de-addiction. Relative and effectiveness is lost by the degree of dropouts and hence relapses. Low-dose DSM had decreased adverse effects with 76.5% patients taking the full course of treatment. DSM alters liver functions as there were significant changes in the lab parameters of SGPT(P=0.007), SGOT(P=0.001), GGT(P=<0.001) between first and third samples. Occurrence of ADR is not the cause of default; patients find it confusing to differentiate between the symptoms of alcohol withdrawal and those due to ADR of DSM.


How to cite this article:
Palatty PL, Saldanha E. Status of disulfiram in present day alcoholic deaddiction therapy.Indian J Psychiatry 2011;53:25-29


How to cite this URL:
Palatty PL, Saldanha E. Status of disulfiram in present day alcoholic deaddiction therapy. Indian J Psychiatry [serial online] 2011 [cited 2020 Jan 20 ];53:25-29
Available from: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2011;volume=53;issue=1;spage=25;epage=29;aulast=Palatty;type=0