Year : 2013  |  Volume : 55  |  Issue : 1  |  Page : 81--83

Off label use of lithium in the treatment of Huntington俟Q製 disease: A case series


Vijay Danivas1, Nagaraj S Moily1, Rohini Thimmaiah1, Kesavan Muralidharan1, Meera Purushotham1, Uday Muthane2, Sanjeev Jain1 
1 Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India
2 Parkinson's and Ageing Research Foundation, Bangalore, Karnataka, India

Correspondence Address:
Vijay Danivas
Department of Psychiatry, National Institute of Mental Health and NeuroSciences, Bangalore - 560 029, Karnataka
India

Huntington俟Q製 disease is characterized by choreic movements, psychiatric disorders, striatal atrophy with selective small neuronal loss, and autosomal dominant inheritance. The genetic abnormality is CAG expansion in Huntingtin gene. Newer therapeutic strategies are evolving to treat this progressive disorder. The neuroprotective agents are one such group of drugs being tried. Lithium has been used to treat Huntington俟Q製 disease in the past due to its neuroprotective effects. Though the precise mechanism of action is not clear, Lithium can directly or indirectly modulate proteins involved in neuronal survival/differentiation which may account for its neuroprotective effects. We report three patients with Huntington俟Q製 disease in whom Lithium prevented the progression of chorea and also helped stabilize mood.


How to cite this article:
Danivas V, Moily NS, Thimmaiah R, Muralidharan K, Purushotham M, Muthane U, Jain S. Off label use of lithium in the treatment of Huntington's disease: A case series.Indian J Psychiatry 2013;55:81-83


How to cite this URL:
Danivas V, Moily NS, Thimmaiah R, Muralidharan K, Purushotham M, Muthane U, Jain S. Off label use of lithium in the treatment of Huntington's disease: A case series. Indian J Psychiatry [serial online] 2013 [cited 2020 Aug 4 ];55:81-83
Available from: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2013;volume=55;issue=1;spage=81;epage=83;aulast=Danivas;type=0