Year : 2014  |  Volume : 56  |  Issue : 1  |  Page : 17--23

Role of nicotine receptor partial agonists in tobacco cessation


Nivedita Maity1, Prabhat Chand2, Pratima Murthy2 
1 Department of Pharmacology, M S Ramaiah Medical College, Bengaluru, Karnataka, India
2 Department of Psychiatry, Centre for Addiction Medicine and Tobacco Cessation Centre, NIMHANS, Bengaluru, Karnataka, India

Correspondence Address:
Pratima Murthy
Department of Psychiatry, Centre for Addiction Medicine and Tobacco Cessation Centre, NIMHANS, Bengaluru, Karnataka
India

One in three adults in India uses tobacco, a highly addictive substance in one or other form. In addition to prevention of tobacco use, offering evidence-based cessation services to dependent tobacco users constitutes an important approach in addressing this serious public health problem. A combination of behavioral methods and pharmacotherapy has shown the most optimal results in tobacco dependence treatment. Among currently available pharmacological agents, drugs that preferentially act on the α4 β2-nicotinic acetyl choline receptor like varenicline and cytisine appear to have relatively better cessation outcomes. These drugs are in general well tolerated and have minimal drug interactions. The odds of quitting tobacco use are at the very least doubled with the use of partial agonists compared with placebo and the outcomes are also superior when compared to nicotine replacement therapy and bupropion. The poor availability of partial agonists and specifically the cost of varenicline, as well as the lack of safety data for cytisine has limited their use world over, particularly in developing countries. Evidence for the benefit of partial agonists is more robust for smoking rather than smokeless forms of tobacco. Although more studies are needed to demonstrate their effectiveness in different populations of tobacco users, present literature supports the use of partial agonists in addition to behavioral methods for optimal outcome in tobacco dependence.


How to cite this article:
Maity N, Chand P, Murthy P. Role of nicotine receptor partial agonists in tobacco cessation.Indian J Psychiatry 2014;56:17-23


How to cite this URL:
Maity N, Chand P, Murthy P. Role of nicotine receptor partial agonists in tobacco cessation. Indian J Psychiatry [serial online] 2014 [cited 2020 Feb 18 ];56:17-23
Available from: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2014;volume=56;issue=1;spage=17;epage=23;aulast=Maity;type=0