Year : 2019  |  Volume : 61  |  Issue : 7  |  Page : 58--65

Glutamatergic augmentation strategies in obsessive–compulsive disorder


Karthik Sheshachala, Janardhanan C Narayanaswamy 
 Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Janardhanan C Narayanaswamy
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru - 560 029, Karnataka
India

Proven treatment strategies for obsessive compulsive disorder (OCD) include pharmacotherapy with serotonin reuptake inhibitors and cognitive behavior therapy (CBT). A significant proportion of patients (25%–30%) fail to respond to these treatment options, necessitating the need for additional treatment options to improve treatment outcomes and quality of life in patients with OCD. Augmentation strategies using various glutamatergic agents have been explored, with diverse outcomes. The aim of this review is to give an overview of the glutamatergic system in the brain with a focus on glutamatergic abnormalities in OCD and to review the existing evidence for various glutamatergic agents used for augmentation.


How to cite this article:
Sheshachala K, Narayanaswamy JC. Glutamatergic augmentation strategies in obsessive–compulsive disorder.Indian J Psychiatry 2019;61:58-65


How to cite this URL:
Sheshachala K, Narayanaswamy JC. Glutamatergic augmentation strategies in obsessive–compulsive disorder. Indian J Psychiatry [serial online] 2019 [cited 2020 Apr 5 ];61:58-65
Available from: http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2019;volume=61;issue=7;spage=58;epage=65;aulast=Sheshachala;type=0