Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 1991  |  Volume : 33  |  Issue : 1  |  Page : 27-32

Prediction of Outcome in Schizophrenia Using the Subjective Response to a Test Dose of a Neuroleptic

1 Consultant Psychiatrist, Davis Institute of Neuropsychiatry, Kanke, Ranchi, India
2 Professor of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, India

Correspondence Address:
Milind Borde
Consultant Psychiatrist, Davis Institute of Neuropsychiatry, Kanke, Ranchi
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Source of Support: None, Conflict of Interest: None

PMID: 21897458

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Twenty four patients meeting R . D .C criteria for schizophrenia were assessed using the B.P.R.S. before starting neuroleptics. They were then given a standardized test dose of haloperidol. Their subjective response to the test dose was assessed 4 hours later by a blind rater. The B.P.R.S. ratings were repeated after 3 weeks of neuroleptic treatment. A dysphoric response to the test dose was associated with a poor therapeutic outcome. The implications of these findings are discussed.



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