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| Year : 1991 | Volume
: 33
| Issue : 1 | Page : 27-32 |
Prediction of Outcome in Schizophrenia Using the Subjective Response to a Test Dose of a Neuroleptic
Milind Borde1, Elizabeth J.B. Davis1, LN Sharma2
1 Consultant Psychiatrist, Davis Institute of Neuropsychiatry, Kanke, Ranchi, India
2 Professor of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, India
Correspondence Address:
Milind Borde
Consultant Psychiatrist, Davis Institute of Neuropsychiatry, Kanke, Ranchi
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 21897458 
Twenty four patients meeting R . D .C criteria for schizophrenia were assessed using the B.P.R.S. before starting neuroleptics. They were then given a standardized test dose of haloperidol. Their subjective response to the test dose was assessed 4 hours later by a blind rater. The B.P.R.S. ratings were repeated after 3 weeks of neuroleptic treatment. A dysphoric response to the test dose was associated with a poor therapeutic outcome. The implications of these findings are discussed.
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