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| Year : 1992 | Volume
: 34
| Issue : 3 | Page : 260-263 |
Clinical Efficacy of Centporpazine a New Antidepressant
JS Srivastava1, PP Gupta1, OP Asthana1, S Nityanand1, S Devi2, DR Doongaji3, BB Sethi4, Gurmeet Singh5, RC Srimal1, BN Dhawan1
1 Central Drug Research Institute, Lucknow, India
2 Former Head, Department of Psychiatry, R.M.L. Hospital, New Delhi, India
3 Former Professor & Head, Department of Psychiatry, Seth G.S. Medical College, Bombay, India
4 Former Professor & Head, Department of Psychiatry, K.G's Medical College, Lucknow, India
5 Professor & Head, Department of Psychiatry, Govt. Medical College, Patiala, India
Correspondence Address:
R C Srimal
Senior Deputy Director & Head, Division of Clinical Pharmacology, Central Drug Research Institute, Lucknow
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 21776129 
Efficacy of centpropazine, a new antidepressant, has been evaluated in forty two patients of endogenous depression. The 4 week open trial was carried out in a dose-range of 40 to 120mg per day. A significant lowering of Hamilton Depression Rating Scale (HDRS) score was observed in 34 patient. The antidepressant effect could be detected in 9 patients within one week, in 28 cases in two weeks and in all the 34 patients by third week. Giddiness, headache, dryness of mouth and weakness were reported by 11 patients.
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