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| Year : 1993 | Volume
: 35
| Issue : 3 | Page : 179-180 |
BR - 16A does not Interfere with Alpha - 2 Noradrenergic and Dopamine Postsynaptic Receptor Functioning
Chittaranjan Andrade1, Jenniffer George2, Thangam Joseph3
1 Associate Professor, Department of Psychopharmacology, NIMHANS, Bangalore - 560 029, India
2 Lecturer, Department of Pharmacology, St. John's Medical College, Bangalore, India
3 Professor and Head, Department of Pharmacology, St. John's Medical College, Bangalore, India
Correspondence Address:
Chittaranjan Andrade
Associate Professor, Department of Psychopharmacology, NIMHANS, Bangalore - 560 029
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 21743635 
BR-16A is a herbal preparation with several putative psychotropic effects. Recent work has suggested that it facilities certain aspects of cognition and that it ameliorates ECT-induced amnesia in animal models. The present study sought to assess whether it affects noradrenergic and dopaminergic functioning in the central nervous system. Adult male Sprague-Dawley rats received BR-16A (200mg/kg) or vehicle for one month. The animals were subsequently challenged with clonidine (100 mg/kg I.P.), apomorphine (2mg/kg I.P.), or saline in a factorial design, and motility of the animals was immediately thereafter assessed using a small open field. BR-16A neither attenuated clonidine induced alpha-2 noradrenergic receptor-mediated hypomotility nor accentuated apomorphine-induced dopamine postsynaptic receptor-mediated hypermotility, suggesting that it does not interfere with alpha-2 noradrenergic and dopamine postsynaptic receptor functioning.
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