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Year : 1998  |  Volume : 40  |  Issue : 1  |  Page : 70-72

Clozapine-induced Agranulocytosis and Use of G-CSF

1 Research Consultant, Schizophrenia Research Foundation (India), Plot R/7A, West Main Road, Chennai-600101, India
2 Consultant Paediatrician, Sundaram Medical Foundation, 4th Avenue, Shanthi Colony, Anna nagar (West), Chennai - 600 040, India

Correspondence Address:
T N Srinivasan
Research Consultant, Schizophrenia Research Foundation (India), Plot R/7A, West Main Road, Chennai-600101
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Source of Support: None, Conflict of Interest: None

PMID: 21494447

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Use of clozapine is attended with the serious though rare risk of agranulocytosis. Clozapineinduced agranulocytosis is reversible with the use of cytokines like granulocyte-colony stimulating factor (G-CSF). Reports of the haematological complication of clozapine have not been forthcoming from India though it has been in use for nearly three years. This report is on an young patient who developed total absence of granulocytes during the 4th month of treatment who was successfully treated with G-CSF.



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