Indian Journal of PsychiatryIndian Journal of Psychiatry
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Year : 1998  |  Volume : 40  |  Issue : 1  |  Page : 84-86

Refractory Schizophrenia, Clozapine and Epilepsy : Management Strategies

1 Resident, Central Institute of Psychiatry, Ranchi - 834006, India
2 Professor of Psychiatry, Central Institute of Psychiatry, Ranchi - 834006, India

Correspondence Address:
Haque S Nizamie
Professor of Psychiatry, Central Institute of Psychiatry, Ranchi - 834006
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Source of Support: None, Conflict of Interest: None

PMID: 21494450

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This case of refractory schizophrenia in a 28 year old male showed significant improvement with clozapine. But therapeutic doses of clozapine were associated with generalised tonic clonic seizures (GTCS). Addition of sodium valproate allowed adequate control of schizophrenic symptoms as well as seizures. EEG abnormality correlated surprisingly well with development of GTCS and subsequent improvement with anticonvulsant. Factors that lead to seizure-vulnerability in clozapine treated patients are discussed.



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