Indian Journal of PsychiatryIndian Journal of Psychiatry
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ARTICLE
Year : 1999  |  Volume : 41  |  Issue : 3  |  Page : 197-202

Hypothalamic Digoxin and Schizophrenia - A Model for Conscious and Subliminal Perception and its Dysfunction in Schizophrenia


1 Assistant Professor of Neurology, Medical college Hospital, Trivandrum, Kerala, India
2 Research Fellow, Department of Biochemistry, University of Kerala, Kerala, India
3 Ph.D., Professor and Chairman of Biochemistry (Rtd), University of Kerala, Kerala, India

Correspondence Address:
P A Kurup
Ph.D., Professor and Chairman of Biochemistry (Rtd), University of Kerala, Kerala
India
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Source of Support: None, Conflict of Interest: None


PMID: 21455390

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In view of reports of an upregulated cation pump in genetically related Bipolar Affective Disorders the role of hypothalamic digoxin, an endogenous regulator of the cation pump was studied with special reference to its role as a modulator of glycoprotein synthesis. The study demonstrated elevated serum digoxin levels, elevated HMG CoA reductase activity suggesting increased digoxin synthesis, reduced sodium-potassium ATPase activity and altered sugar residues of serum glycoprotein in schizophrenia. A hypothalamic digoxin mediated model for conscious and subliminal perception is proposed and the significance of its dysfunction due to abnormal glycoprotein induced synaptic connectivity defects in schizophrenia is discussed.



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