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Year : 2000  |  Volume : 42  |  Issue : 4  |  Page : 410-414

Long Term Effects of Lithium on Glomerular Filtration Rate in Indian Subjects - A Cross Sectional Study

1 Assistant Professor, Department of Nuclear Medicine, PGlMER, Chandigarh -160012, India
2 Assistant Professor, Department of Nephrology, PGlMER, Chandigarh -160012, India
3 Assistant Professor, Department of Psychiatry, PGlMER, Chandigarh -160012, India
4 Professor, Department of Nuclear Medicine, PGlMER, Chandigarh -160012, India

Correspondence Address:
Baljinder Singh
Assistant Professor, Department of Nuclear Medicine, PGlMER, Chandigarh -160012
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Source of Support: None, Conflict of Interest: None

PMID: 21407979

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Glomerular filtration rate (GFR) was evaluated in thirty patients on lithium and in thirty healthy prospective kidney donors by single compartment, multiple sample plasma clearance method using 99m Technetium diethylene triamine pentaacetic acid ( 99m TC-DTPA). Normality test revealed that dose and treatment duration were skewed and the coefficient of skewness were 0.067 (p<0.0001) and 1.41 (p<0.0001) respectively. Age was marginally skewed (p =0.04) for the control group. At 5% significance level, dose and creatinine were negatively correlated (r=-0.030), whereas age and duration were positively correlated (r =+ 0.53) (single tailed only). Duration and GFR seems to be negatively correlated (r = -0.23), however this correlation did not reach statistically significance level. In the present cross sectional study no significant difference in mean GFR was observed in lithium treated affective disorder patients when compared with the age matched normal subjects.



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