Indian Journal of PsychiatryIndian Journal of Psychiatry
Home | About us | Current Issue | Archives | Ahead of Print | Submission | Instructions | Subscribe | Advertise | Contact | Login 
    Users online: 4892 Small font sizeDefault font sizeIncrease font size Print this article Email this article Bookmark this page
Search Again
 Table of Contents
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Article Access Statistics
 Reader Comments
 Email Alert
 Add to My List
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded182    
    Comments [Add]    

Recommend this journal

Year : 2004  |  Volume : 46  |  Issue : 3  |  Page : 261-266

A Comparative Study of Sexual Dysfunction Due to Typical and Atypical Antipsychotics in Remitted Bipolar-I Disorder

1 Junior Resident, Central Institute of Psychiatry, Ranchi-834 006, India
2 Professor of Psychiatry and Director, Central Institute of Psychiatry, Ranchi-834 006, India
3 Chief Medical Officer and Consultant in Psychiatry, Central Institute of Psychiatry, Ranchi-834 006, India
4 Senior Resident, Central Institute of Psychiatry, Ranchi-834 006, India

Correspondence Address:
Haque S Nizamie
Professor of Psychiatry and Director, Central Institute of Psychiatry, Ranchi-834 006
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 21224908

Rights and PermissionsRights and Permissions

In the remitted phase of bipolar I disorder, sexual dysfunction is commonly due to drugs used in the treatment rather than the disease itself. There are very few studies, especially in the Indian population, addressing the frequency of sexual dysfunction due to antipsychotics in bipolar I disorder. Hence this study was done to determine the sexual dysfunction due to antipsychotics and to compare the same among typical and atypical antipsychotics. A cross sectional study with 108 male patients of remitted bipolar I disorder (DSM-IV), chosen by purposive sampling technique was done. Psychopathology was assessed using the Brief Psychiatric Rating Scale, Structured Interview Guide for the Hamilton Depression Rating Scale and Young Mania Rating Scale. Sexual side effects due to antipsychotics were assessed using the Udvalg for Kliniske ndersogelser (UKU) side effect rating scale. The total sample size was divided into two groups of those on typical antipsychotics (n = 53) and atypical antipsychotics (n = 55). The two groups were compared for sexual dysfunction using Chi-square test. Results showed dysfunction in at least one phase of the sexual response cycle, comprising of desire, arousal and orgasm, was present in 66% of the sample population. Erectile dysfunction was present in 42% of the sample population and it was the most common type of sexual dysfunction reported. It was also significantly different across the two groups (p = 0.025). There was no significant difference in other aspects of sexual dysfunction across the two groups. In conclusion patients of Bipolar I disorder experience sexual side effects of antipsychotics frequently. Erectile dysfunction is the most common sexual dysfunction among men and this is significantly higher with typical than atypical antipsychotics.



Print this article         Email this article