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Year : 2005  |  Volume : 47  |  Issue : 2  |  Page : 121-123

Stevens-Johnson syndrome-toxic epidermal necrolysis (SJS-TEN) overlap associated with carbamazepine use

Institute of Mental Health and Neurosciences, Kozhikode

Correspondence Address:
P N Suresh Kumar
Institute of Mental Health and Neurosciences, Kozhikode

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5545.55961

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A benign pruritic rash occurs in 10%-15% of persons treated with carbamazepine. A small fraction of them may experience life-threatening dermatological syndromes such as exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The case of an 18-year-old female suffering from bipolar affective disorder (mania) who was being treated with carbamazepine, lithium, chlorpromazine and benzhexol is presented. After 10 days of treatment, she developed high-grade fever and mucocutaneous manifestations of SJS-TEN overlap. She was treated in hospital with systemic corticosteroids, antibiotics, intravenous fluids and other supportive measures, and recovered after 3 weeks.



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