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 Table of Contents    
Year : 2011  |  Volume : 53  |  Issue : 2  |  Page : 95-96
The MMR vaccine and autism: Sensation, refutation, retraction, and fraud

1 Department of Psychiatry, JSS Medical College Hospital, Mysore, India
2 Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India

Click here for correspondence address and email

Date of Web Publication30-Jun-2011

How to cite this article:
Sathyanarayana Rao T S, Andrade C. The MMR vaccine and autism: Sensation, refutation, retraction, and fraud. Indian J Psychiatry 2011;53:95-6

How to cite this URL:
Sathyanarayana Rao T S, Andrade C. The MMR vaccine and autism: Sensation, refutation, retraction, and fraud. Indian J Psychiatry [serial online] 2011 [cited 2021 Oct 28];53:95-6. Available from:

In 1998, Andrew Wakefield and 12 of his colleagues [1] published a case series in the Lancet, which suggested that the measles, mumps, and rubella (MMR) vaccine may predispose to behavioral regression and pervasive developmental disorder in children. Despite the small sample size (n=12), the uncontrolled design, and the speculative nature of the conclusions, the paper received wide publicity, and MMR vaccination rates began to drop because parents were concerned about the risk of autism after vaccination. [2]

Almost immediately afterward, epidemiological studies were conducted and published, refuting the posited link between MMR vaccination and autism. [3],[4] The logic that the MMR vaccine may trigger autism was also questioned because a temporal link between the two is almost predestined: both events, by design (MMR vaccine) or definition (autism), occur in early childhood.

The next episode in the saga was a short retraction of the interpretation of the original data by 10 of the 12 co-authors of the paper. According to the retraction, "no causal link was established between MMR vaccine and autism as the data were insufficient". [5] This was accompanied by an admission by the Lancet that Wakefield et al.[1] had failed to disclose financial interests (e.g., Wakefield had been funded by lawyers who had been engaged by parents in lawsuits against vaccine-producing companies). However, the Lancet exonerated Wakefield and his colleagues from charges of ethical violations and scientific misconduct. [6]

The Lancet completely retracted the Wakefield et al.[1] paper in February 2010, admitting that several elements in the paper were incorrect, contrary to the findings of the earlier investigation. [7] Wakefield et al.[1] were held guilty of ethical violations (they had conducted invasive investigations on the children without obtaining the necessary ethical clearances) and scientific misrepresentation (they reported that their sampling was consecutive when, in fact, it was selective). This retraction was published as a small, anonymous paragraph in the journal, on behalf of the editors. [8]

The final episode in the saga is the revelation that Wakefield et al.[1] were guilty of deliberate fraud (they picked and chose data that suited their case; they falsified facts). [9] The British Medical Journal has published a series of articles on the exposure of the fraud, which appears to have taken place for financial gain. [10],[11],[12],[13] It is a matter of concern that the exposé was a result of journalistic investigation, rather than academic vigilance followed by the institution of corrective measures. Readers may be interested to learn that the journalist on the Wakefield case, Brian Deer, had earlier reported on the false implication of thiomersal (in vaccines) in the etiology of autism. [14] However, Deer had not played an investigative role in that report. [14]

The systematic failures which permitted the Wakefield fraud were discussed by Opel et al.[15]

   Implications Top

Scientists and organizations across the world spent a great deal of time and money refuting the results of a minor paper in the Lancet and exposing the scientific fraud that formed the basis of the paper. Appallingly, parents across the world did not vaccinate their children out of fear of the risk of autism, thereby exposing their children to the risks of disease and the well-documented complications related thereto. Measles outbreaks in the UK in 2008 and 2009 as well as pockets of measles in the USA and Canada were attributed to the nonvaccination of children. [7] The Wakefield fraud is likely to go down as one of the most serious frauds in medical history. [9]

Scientists who publish their research have an ethical responsibility to ensure the highest standards of research design, data collection, data analysis, data reporting, and interpretation of findings; there can be no compromises because any error, any deceit, can result in harm to patients as well harm to the cause of science, as the Wakefield saga so aptly reveals. We sincerely hope that researchers will keep this ethical responsibility in mind when they submit their manuscripts to the Indian Journal of Psychiatry.

   References Top

1.Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998;351:637-41.   Back to cited text no. 1
2.DeStefano F, Chen RT. Negative association between MMR and autism. Lancet 1999;353:1987-8.  Back to cited text no. 2
3.Taylor B, Miller E, Farrington CP, Petropoulos MC, Favot-Mayaud I, Li J, et al. Autism and measles, mumps, and rubella vaccine: No epidemiologic evidence for a causal association. Lancet 1999;353:2026-9.  Back to cited text no. 3
4.Dales L, Hammer SJ, Smith NJ. Time trends in autism and in MMR immunization coverage in California. JAMA 2001;285:1183-5.  Back to cited text no. 4
5.Murch SH, Anthony A, Casson DH, Malik M, Berelowitz M, Dhillon AP, et al. Retraction of an interpretation. Lancet 2004;363:750.  Back to cited text no. 5
6.Horton R. A statement by the editors of The Lancet. Lancet 2004;363:820-1.  Back to cited text no. 6
7.Eggertson L. Lancet retracts 12-year-old article linking autism to MMR vaccines. CMAJ 2010;182:E199-200.   Back to cited text no. 7
8.Anonymous. Retraction-Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 2010;375:445.  Back to cited text no. 8
9.Godlee F. The fraud behind the MMR scare. BMJ 2011;342:d22.  Back to cited text no. 9
10.Deer B. Wakefield's "autistic enterocolitis" under the microscope. BMJ 2010;340:c1127.   Back to cited text no. 10
11.Deer B. How the case against the MMR vaccine was fixed. BMJ 2011;342:c5347.   Back to cited text no. 11
12.Deer B. Secrets of the MMR scare. How the vaccine crisis was meant to make money. BMJ 2011;342:c5258.  Back to cited text no. 12
13.Deer B. Secrets of the MMR scare. The Lancet's two days to bury bad news. BMJ 2011;342:c7001.  Back to cited text no. 13
14.Deer B. Autism research: What makes an expert? BMJ 2007;334:666-7.   Back to cited text no. 14
15.Opel DJ, Diekema DS, Marcuse EK. Assuring research integrity in the wake of Wakefield. BMJ 2011;342:d2.  Back to cited text no. 15

Correspondence Address:
T S Sathyanarayana Rao
Department of Psychiatry, JSS University, JSS Medical College Hospital, M.G. Road, Mysore - 570004, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5545.82529

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