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CASE REPORT
Year : 2013  |  Volume : 55  |  Issue : 2  |  Page : 186-188

Intramuscular ketamine in acute depression: A report on two cases


Department of Psychiatry, Narayana Medical College, Nellore, Andhra Pradesh, India

Correspondence Address:
Chilukuri Harihar
Department of Psychiatry, Narayana Medical College, Chintareddy Palem, Nellore, Andhra Pradesh - 524 002
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5545.111461

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It takes about 2 weeks for the onset of antidepressant action of drugs while electroconvulsive therapy though faster, is a cumbersome procedure requiring an anaesthetist and at least a minor operation theatre. Recent studies have shown that Ketamine, when given to severely depressed patients in the dose of 0.5 mg/kg as a slow intravenous infusion over 40 minutes, brought about acute relief from depression and amelioration of suicidal risk within a few hours. The improvement, however, was transient and lasted for up to a week but could be sustained by further weekly or biweekly injections. As the dose of ketamine administered was found to be safe, it was now tried in the intramuscular route in two severely depressed patients with similar rapid improvement. The cases are reported here which pave way for an easier mode of treating acute depression.



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