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|Year : 2015 | Volume
| Issue : 3 | Page : 272-277
Childhood autism in India: A case-control study using tract-based spatial statistics analysis
Zarina Abdul Assis1, Bhavani Shankara Bagepally2, Jitender Saini1, Shoba Srinath3, Rose Dawn Bharath1, Purushotham R Naidu4, Arun Kumar Gupta1
1 Department of NIIR, NIMHANS, Bengaluru, Karnataka, India
2 Department of Neurosciences, NIMHANS, Bengaluru, Karnataka, India
3 Department of Child and Adolescent Psychiatry, NIMHANS, Bengaluru, Karnataka, India
4 Senior Medical Advisor, Biocon Ltd, Bengaluru, Karnataka, India
Context: Autism is a serious behavioral disorder among young children that now occurs at epidemic rates in developing countries like India. We have used tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) measures to investigate the microstructure of primary neurocircuitry involved in autistic spectral disorders as compared to the typically developed children.
Objective: To evaluate the various white matter tracts in Indian autistic children as compared to the controls using TBSS.
Materials and Methods: Prospective, case-control, voxel-based, whole-brain DTI analysis using TBSS was performed. The study included 19 autistic children (mean age 8.7 years ± 3.84, 16 males and 3 females) and 34 controls (mean age 12.38 ± 3.76, all males). Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) values were used as outcome variables.
Results: Compared to the control group, TBSS demonstrated multiple areas of markedly reduced FA involving multiple long white matter tracts, entire corpus callosum, bilateral posterior thalami, and bilateral optic tracts (OTs). Notably, there were no voxels where FA was significantly increased in the autism group. Increased RD was also noted in these regions, suggesting underlying myelination defect. The MD was elevated in many of the projections and association fibers and notably in the OTs. There were no significant changes in the AD in these regions, indicating no significant axonal injury. There was no significant correlation between the FA values and Childhood Autism Rating Scale.
Conclusion: This is a first of a kind study evaluating DTI findings in autistic children in India. In our study, DTI has shown a significant fault with the underlying intricate brain wiring system in autism. OT abnormality is a novel finding and needs further research.
Zarina Abdul Assis
Department of NIIR, NIMHANS, Bengaluru - 560 066, Karnataka
Source of Support: None, Conflict of Interest: None
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