Indian Journal of PsychiatryIndian Journal of Psychiatry
Home | About us | Current Issue | Archives | Ahead of Print | Submission | Instructions | Subscribe | Advertise | Contact | Login 
    Users online: 1564 Small font sizeDefault font sizeIncrease font size Print this article Email this article Bookmark this page


    Advanced search

    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  

    Cognitive Dysfun...
    What Causes Thes...
    Herpes Simplex V...
    Herpes Simplex V...
    Herpes Simplex V...
    Herpes Simplex V...
    Mechanisms for t...
    Indian Herpes Si...

 Article Access Statistics
    PDF Downloaded174    
    Comments [Add]    

Recommend this journal


 Table of Contents    
Year : 2018  |  Volume : 60  |  Issue : 4  |  Page : 393-397
Exploring the associations of herpes simplex virus infection and cognitive dysfunction in schizophrenia: Studies in India

1 Centre of Excellence in Mental Health, PGIMER and Dr. Ram Manohar Lohia Hospital, New Delhi, India
2 Department of Psychiatry and Genetics, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA

Click here for correspondence address and email

Date of Web Publication28-Nov-2018


Background: Cognitive dysfunctions being core features of schizophrenia (SZ), cause disability, increase burden and are refractory to treatment. Viral infections are not risk factors for SZ, but growing evidence indicates infection with some neurotropic viruses, particularly Herpes simplex virus type 1 (HSV -1) as a risk factor for cognitive dysfunction.
Studies in India: Three research studies in India are described. In the first, participants were evaluated for HSV-1 infection and cognitive functions (cases 198 and controls 100). In the second, patients and normal nonpsychotic control individuals were examined at baseline and followed up over 1–3 years (cases 138 and controls 88). In the third, a randomized, double-blind placebo-controlled antipsychotic adjunctive trial was conducted to examine the effect of anti-viral drug valacyclovir over 16 weeks on cognitive functioning (valacyclovir 30; placebo 32, treatment for 16 weeks).
Results of Indian Studies: Cross-sectional study: HSV-1 infection was associated with modest dysfunction, especially on attention (accuracy) and spatial processing (speed).
Longitudinal Study: HSV-1 seropositive participants had lower scores at baseline on 6/16 measures, regardless of SZ diagnoses. At follow-up, there was a significant decline in HSV-1-positive participants for abstraction and mental flexibility and emotion discrimination.
Randomized Controlled Trial: Significantly, greater improvement in accuracy index of emotion discrimination in the valacyclovir-treated versus placebo sample was found.
Conclusions: Indian studies are consistent with a causative role for HSV-1 in cognitive dysfunction regardless of SZ diagnosis; more rigorous studies of the causal hypothesis are needed, particularly larger randomized controlled trials.

Keywords: Cognition, herpes simplex virus type 1, schizophrenia

How to cite this article:
Deshpande SN, Nimgaonkar VL. Exploring the associations of herpes simplex virus infection and cognitive dysfunction in schizophrenia: Studies in India. Indian J Psychiatry 2018;60:393-7

How to cite this URL:
Deshpande SN, Nimgaonkar VL. Exploring the associations of herpes simplex virus infection and cognitive dysfunction in schizophrenia: Studies in India. Indian J Psychiatry [serial online] 2018 [cited 2020 Nov 23];60:393-7. Available from:

   Cognitive Dysfunction in Schizophrenia Top

Since its first description as dementia praecox, it has been recognized that schizophrenia (SZ) is associated with cognitive dysfunction which may be a core feature of the illness,[1] occurring in all phases of the illness;[2] indeed, cognitive dysfunction may predate a diagnosis of SZ by several years.[3],[4] Sufferers may be unaware of these deficits.[5] While deficits have been reported in almost all domains of cognition,[6] the domains most affected are memory, attention, working memory, problem-solving, processing speed, social cognition,[7] as well as impaired executive functioning.[8],[9],[10] However, these deficits can stabilize.[11] Cognitive deficits are often a cause of functional impairment in SZ.[12]

There is a need for systematic research to discover factors that affect cognitive impairment in SZ participants because: (a) Cognitive deficits in SZ cause disability, impair the ability to carry out day-to-day tasks and adversely affect rehabilitation,[12],[13] cognitive deficits impose considerable burden on patients' families,[14] and cognitive functions do not improve appreciably with currently available treatments.[15],[16]

   What Causes These Deficits? Top

There are no definitive etiologic factors, though genetic factors likely play a role. Neurotropic agents are being investigated as risk factors. Herpes viruses have been investigated because they can cause infection in the brain.[17],[18] These viruses can infect humans in early life, and reactivate throughout life.[19]

   Herpes Simplex Virus Type 1 Top

Herpes simplex virus type 1 (HSV-1) is a double-stranded DNA virus. Infection occurs via mucocutaneous junctions, primarily through oral contact, sexual contact (increasingly common), or during childbirth.[20] From the infection site, the virus migrates to sensory ganglia where it remains latent for long periods of time-sometimes even the host's lifetime,[21] becoming active usually during periods of stress or immunosuppression[21],[22] The virus assumes a circular form and produces few if any untranslated viral transcripts during latency[21],[23] The latent virus remains for life in various parts of the nervous system such as the trigeminal ganglia, the cornea, and brain even after acute infection.[24] Following reactivation, the virions migrate along neural processes and infection flares up, typically in mucous membranes, producing cold sores.[21]

HSV-1 infections are common and in vulnerable individuals, can result in encephalitis, Mollaret's meningitis, neonatal herpes, and possibly Bell's palsy. Ocular herpes is one of the chief causes of blindness worldwide, with a global incidence of approximately 1.5 million cases per year, with an estimated 40,000 new cases of visual impairment or blindness annually.[25] During immuno-compromised periods, the recrudescence of the infection may occur. HSV infection has been associated with cognitive deficits of SZ,[26],[27] bipolar disorder,[28],[29],[30] and Alzheimer's disease.[31] Higher antibody titers have been reported in recent-onset SZ[32] and specific subtypes of SZ as well.[28]

Infection can occur at any time-from intrauterine up to adulthood, and its prevalence is inversely related to socioeconomic status (SES). In Western countries, it increases with age up to 90%.[33] Once the active phase is over, HSV infection early in life may affect neurodevelopmental processes which may lead to later cognitive impairment and psychopathology.

Psychiatric symptoms after herpes encephalitis may persist for years.[34],[35] The most prominent cognitive deficits are in working memory, visual object recognition,[36] and anterograde amnesia.[36]

Herpes virus particles in blood or body are typically difficult to detect during the latent phase.[37] However, the indirect proof of infection can be obtained by estimating specific host-generated serum immunoglobulin G antibodies (which remain elevated for prolonged periods).

   Herpes Simplex Virus 1 and Schizophrenia Top

It should be noted that extensive studies between herpes virus exposure and SZ did not present proof of increased SZ risk as such,[38] though an early Indian study reported the significant prevalence of various viral infections in “psychiatric patients” including-cytomegalovirus (CMV), HSV-1, mumps, measles, and varicella-zoster virus.[39]

   Herpes Simplex Virus Type 1 and Cognitive Dysfunction in Nonpsychotic Persons Top

Cognitive impairment may occur among persons without a history of encephalitis due to HSV-1. A study of Finnish patients with vascular disease suggested cumulative effects of exposure to CMV, HSV-1, and HSV-2.[40] Another study of healthy controls reported an association between HSV-1 exposure and impairment in total scores on the Repeated Battery for the Assessment of Neuropsychological Status (RBANS).[41] The same group reported immediate verbal memory deficits among HSV-1 seropositive bipolar patients.[42] Using the memory deficits as a template, others studied the possibility of HSV-1 affecting Alzheimer's disease, but the results were inconsistent[43],[44] To our knowledge, two US studies did not detect significant associations between HSV-1 exposure and cognitive function[45],[46] Patients with bipolar disorder, another group with illness-related cognitive impairments also showed association.[41]

   Herpes Simplex Virus Type 1 and Cognitive Dysfunction in Persons With Schizophrenia Top

Dickerson et al. reported HSV-1 antibody status as an independent predictor of cognitive impairment, specifically of immediate memory (n = 229 outpatients with SZ), using RBANS.[47] Similar associations were reported independently.[27] Later, cognitive dysfunction accompanied by decreased dorsolateral prefrontal cortex volumes were reported among HSV-1 seropositive as compared to seronegative patients with SZ.[47],[48] Prefrontal gray matter volumes (decrease in gray matter in Brodmann areas 9-dorsolateral prefrontal cortex, and 32-anterior cingulate cortex) were significantly correlated with HSV1 serological status among SZ patients.[48]

   Mechanisms for the Association between Herpes Simplex Virus Type 1 Infection and Cognitive Dysfunction Top

The impairment may be explained by several mechanisms, including direct cytopathic effects of reactivation, or secondary to neurotoxic effects of cytokines released during reactivation cycles,[21],[49] The timing for the damage is also uncertain, as it can extend from the perinatal period to adulthood. Cytokine imbalance, reported in some SZ patients may be attributable to HSV-1 seropositivity.[50],[51],[52]

   Indian Herpes Simplex Virus Type 1 Studies Top

Our group has been conducting studies on HSV-1 infections among the Indian population since 2009. A series of projects were undertaken. Results are presented below.

Effect on cognitive functions among nonpsychotic controls and patients with early course of schizophrenia

We began with examining the type and extent of cognitive deterioration associated with HSV-1 exposure among patients with early course SZ or schizoaffective disorder.[53] We recruited nonpsychotic control individuals as well. We assessed eight cognitive domains (accuracy and speed) using the Penn Computerized Neurocognitive Battery (Penn CNB).[54] A total of 298 individuals (cases 198, controls 100) were recruited. Persons with a history of substance abuse, medical or neurological disorders (head injury, encephalitis, and epilepsy) and those unable to complete cognitive tests were excluded. Categorical HSV-1 status (positive, negative, or equivocal) was determined using venous blood sample based on antibodies to HSV-1 in the serum[55] from a commercial laboratory using commercial kits.

We found that the prevalence of HSV-1 exposure was similar among cases and controls. Thus, HSV-1 exposure did not influence the risk of SZ. Patients performed significantly worse on the Penn CNB than controls, regardless of HSV-1 serostatus. HSV-1-positive persons, controlling for age, performed less well on 6/15 CNB domains, for accuracy (abstraction and mental flexibility, attention, spatial memory, and spatial processing) and speed (spatial processing, emotional processing, and sensorimotor dexterity). Thus, HSV-1 exposure was associated with modest, specific localized effects, the largest effect sizes were for attention (accuracy) and spatial processing (speed). Dickerson et al. reported that the difference in cognitive functioning between HSV-1 positive and negative SZ patients could be attributed to immediate verbal memory and that the difference in the controls by HSV-1 status was in delayed memory.[56] We could not study the verbal memory domain in the Penn CNB as it was unavailable in the Hindi version. Thus, we did not find a significant association between exposure to HSV-1 and risk for SZ. On the other hand, significant cognitive dysfunction was detected with respect to several variables among HSV-1 exposed patients and controls, compared with unexposed persons.

Effect of herpes simplex virus exposure on longitudinal cognitive performance

We followed up patients with SZ and controls (recruited participants overlapped with the above project), over 1 or 3 years (ages 18–50 years).[57] We excluded those with neurological disorders, drug abuse or those who could not undergo cognitive assessment. After recruiting 412 participants with due informed consent (SZ n = 265 and controls n = 146), and excluding those with equivocal serological results, 138 persons with SZ and 88 individuals without psychosis were evaluated after at least 1 year. Persons with SZ performed less well on cognitive functions, as in the first study. Across the entire sample, HSV-1 seropositive participants, after controlling for SZ status, had lower scores at baseline on 6/16 measures: accuracy index of abstraction and mental flexibility (P = 0.001), face memory (P = 0.25), spatial memory (P = 0.0002), working memory (P = 0.028), spatial ability (P = 0.001), and emotion (P = 0.001). On speed index of spatial ability (P = 0.004) and sensorimotor (0.014) also, HSV-1 seropositive participants were significantly impaired at baseline. After follow-up of at least 1 year, there was a significant decline in HSV-1 positive participants on abstraction and mental flexibility (P = 0.004) and emotion (P = 0.008). In the entire sample, seropositive individuals at follow-up showed a significantly greater decline, especially in the emotion discrimination domain. Identifying emotions correctly is important for social functioning, and along with emotion perception forms an important part of social cognition.[54],[58],[59]

Can antiviral treatment improve cognition in herpes simplex virus type 1 affected schizophrenia cases?

Given the scale of infection and its possible effect on cognition, a clinical trial of the antiviral agent is warranted. In a small randomized controlled adjunctive (to regular antipsychotics) trial (n = 24),[60] we administered the HSV-1 specific antiviral drug Valacyclovir for 18 weeks versus placebo. They reported significant improvement in verbal memory, working memory, and visual object learning.

We conducted a similar double-blind placebo-controlled randomized 20-week trial with Indian HSV-1 seropositive individuals with SZ.[57] We included early course SZ patients with <7 years of illness, aged 18–50 years, and on stable doses of antipsychotic drugs for ≥1 month at initiation, with a score of ≥4 on any item of the Positive and Negative Symptoms Scale.[61] Stratified random sampling based on age (older or younger than 30 years) and sex was used to place individuals into active group (valacyclovir) or placebo. Antipsychotic dose as far as possible was kept stable through the 20-week trial (valacyclovir 1.5 g by mouth, twice daily or placebo twice daily for 16 weeks, followed by review after 4 more weeks).

We used intention to treat analysis for a final total of 62 patients (valacyclovir 30; placebo 32), and mixed model repeated measures analytical method. A total of 56 participants completed the study (valacyclovir 25; placebo 31). Analyzing intent to treat sample or the completed sample, we found significantly greater improvement in the accuracy index of emotion discrimination in the valacyclovir-treated versus placebo sample (the same cognitive domain that worsened over time in the Indian sample). No serious or major adverse effects were noted. Thus, as in the follow-up sample, the treated sample showed effect on emotion discrimination as well.

   Discussion Top

None of our patients were medication free, and it is possible that antipsychotics may have influenced some of our results. Cycles of active infection alternating with latency periods may affect differing brain areas. If the initial infection had occurred in utero or very early in life, it may have caused subclinical damage which may manifest differentially subsequently. Infection outside the central nervous system with cytokine release which can cross the blood-brain barrier may disrupt cognitive functions,[62],[63] It is well known that infections are more common among those of lower SES. In all our studies, we controlled for SES as well.[64]

What are the implications of our studies? Today adequate cognitive functions are crucial for survival. As such any potentially remediable factor for improving cognition deserves to be investigated in detail. Impaired cognitive functioning has been associated with seropositivity for HSV-1 infection, in varied samples and study designs from different centers. Further studies are warranted to investigate possible etiologic links between persistent HSV-1 infection and cognitive dysfunction in otherwise healthy individuals.

   Conclusions Top

Modifiable factors, such as HSV-1 infection need to be investigated from an etiologic and therapeutic perspective in persons with serious major mental illnesses such as SZ and even in otherwise healthy persons.


The authors are grateful to the funding agencies for this work-Department of Science and Technology Government of India, and Stanley Medical Research Institute, USA. We are grateful to our research participants, co-investigators, and co-authors of our various projects. Dr. T. Bhatia and Sushree Sahu helped with references.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Keefe RS, Fenton WS. How should DSM-V criteria for schizophrenia include cognitive impairment? Schizophr Bull 2007;33:912-20.  Back to cited text no. 1
Verdoux H, Tignol J. Focus on psychiatry in France. Br J Psychiatry 2003;183:466-71.  Back to cited text no. 2
Moritz S, Birkner C, Kloss M, Jacobsen D, Fricke S, Böthern A, et al. Impact of comorbid depressive symptoms on neuropsychological performance in obsessive-compulsive disorder. J Abnorm Psychol 2001;110:653-7.  Back to cited text no. 3
Moritz S, Andresen B, Jacobsen D, Mersmann K, Wilke U, Lambert M, et al. Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics. Eur Psychiatry 2001;16:354-61.  Back to cited text no. 4
van den Bosch RJ, Rombouts RP. Causal mechanisms of subjective cognitive dysfunction in schizophrenic and depressed patients. J Nerv Ment Dis 1998;186:364-8.  Back to cited text no. 5
Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology 1998;12:426-45.  Back to cited text no. 6
Nuechterlein KH, Barch DM, Gold JM, Goldberg TE, Green MF, Heaton RK. Identification of separable cognitive factors in schizophrenia. Schizophr Res 2004;72:29-39.  Back to cited text no. 7
Koren D, Seidman LJ, Harrison RH, Lyons MJ, Kremen WS, Caplan B, et al. Factor structure of the wisconsin card sorting test: Dimensions of deficit in schizophrenia. Neuropsychology 1998;12:289-302.  Back to cited text no. 8
Bustini M, Stratta P, Daneluzzo E, Pollice R, Prosperini P, Rossi A. Tower of hanoi and WCST performance in schizophrenia: Problem-solving capacity and clinical correlates. J Psychiatr Res 1999;33:285-90.  Back to cited text no. 9
Laurent A, d'Amato T, Naegele B, Murry P, Baro P, Foussard N, et al. Executive and amnestic functions of a group of first-degree relatives of schizophrenic patients. Encephale 2000;26:67-74.  Back to cited text no. 10
Kurtz MM, Moberg PJ, Gur RC, Gur RE. Approaches to cognitive remediation of neuropsychological deficits in schizophrenia: A review and meta-analysis. Neuropsychol Rev 2001;11:197-210.  Back to cited text no. 11
Velligan DI, Bow-Thomas CC, Mahurin RK, Miller AL, Halgunseth LC. Do specific neurocognitive deficits predict specific domains of community function in schizophrenia? J Nerv Ment Dis 2000;188:518-24.  Back to cited text no. 12
Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the “right stuff"? Schizophr Bull 2000;26:119-36.  Back to cited text no. 13
Elvevåg B, Goldberg TE. Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiol 2000;14:1-21.  Back to cited text no. 14
Meltzer HY, McGurk SR. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophr Bull 1999;25:233-55.  Back to cited text no. 15
McGurk SR, Twamley EW, Sitzer DI, McHugo GJ, Mueser KT. A meta-analysis of cognitive remediation in schizophrenia. Am J Psychiatry 2007;164:1791-802.  Back to cited text no. 16
Cairns TM, Milne RS, Ponce-de-Leon M, Tobin DK, Cohen GH, Eisenberg RJ. Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: Clues from gDgH chimeras. J Virol 2003;77:6731-42.  Back to cited text no. 17
Whitley RJ. Viral Infections of the Central Nervous System. In: Cohen J, Powderly WG, editors. Infectious Diseases. 2nd ed. Edinburgh, New York: Mosby; 2004. p. 267-78.  Back to cited text no. 18
Yolken RH, Torrey EF. Are some cases of psychosis caused by microbial agents? A review of the evidence. Mol Psychiatry 2008;13:470-9.  Back to cited text no. 19
Kriebs JM. Understanding herpes simplex virus: Transmission, diagnosis, and considerations in pregnancy management. J Midwifery Womens Health 2008;53:202-8.  Back to cited text no. 20
Steiner I, Kennedy PG, Pachner AR. The neurotropic herpes viruses: Herpes simplex and varicella-zoster. Lancet Neurol 2007;6:1015-28.  Back to cited text no. 21
Shimomura Y, Higaki S. The kinetics of herpes virus on the ocular surface and suppression of its reactivation. Cornea 2011;30 Suppl 1:S3-7.  Back to cited text no. 22
Harkness JM, Kader M, DeLuca NA. Transcription of the herpes simplex virus 1 genome during productive and quiescent infection of neuronal and nonneuronal cells. J Virol 2014;88:6847-61.  Back to cited text no. 23
Cleator GM, Klapper PE. The herpesviridae. In: Zuckerman AJ, Bantavala JE, Pattison JR, Griffiths PD, Schoub BD, editors. Priniciples and Practice of Clinical Virology. 5th ed. Hoboken, NJ: John Wiley & Sons; 2004. p. 23-6.  Back to cited text no. 24
Farooq AV, Shukla D. Herpes simplex epithelial and stromal keratitis: An epidemiologic update. Surv Ophthalmol 2012;57:448-62.  Back to cited text no. 25
Schretlen DJ, Vannorsdall TD, Winicki JM, Mushtaq Y, Hikida T, Sawa A, et al. Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia. Schizophr Res 2010;118:224-31.  Back to cited text no. 26
Shirts BH, Prasad KM, Pogue-Geile MF, Dickerson F, Yolken RH, Nimgaonkar VL, et al. Antibodies to cytomegalovirus and herpes simplex virus 1 associated with cognitive function in schizophrenia. Schizophr Res 2008;106:268-74.  Back to cited text no. 27
Dickerson F, Kirkpatrick B, Boronow J, Stallings C, Origoni A, Yolken R, et al. Deficit schizophrenia: Association with serum antibodies to cytomegalovirus. Schizophr Bull 2006;32:396-400.  Back to cited text no. 28
Dickerson FB, Boronow JJ, Stallings C, Origoni AE, Cole S, Krivogorsky B, et al. Infection with herpes simplex virus type 1 is associated with cognitive deficits in bipolar disorder. Biol Psychiatry 2004;55:588-93.  Back to cited text no. 29
Tanaka T, Matsuda T, Hayes LN, Yang S, Rodriguez K, Severance EG, et al. Infection and inflammation in schizophrenia and bipolar disorder. Neurosci Res 2017;115:59-63.  Back to cited text no. 30
Honjo K, van Reekum R, Verhoeff NP. Alzheimer's disease and infection: Do infectious agents contribute to progression of Alzheimer's disease? Alzheimers Dement 2009;5:348-60.  Back to cited text no. 31
Leweke FM, Gerth CW, Koethe D, Klosterkötter J, Ruslanova I, Krivogorsky B, et al. Antibodies to infectious agents in individuals with recent onset schizophrenia. Eur Arch Psychiatry Clin Neurosci 2004;254:4-8.  Back to cited text no. 32
Smith JS, Robinson NJ. Age-specific prevalence of infection with herpes simplex virus types 2 and 1: A global review. J Infect Dis 2002;186 Suppl 1:S3-28.  Back to cited text no. 33
McGrath N, Anderson NE, Croxson MC, Powell KF. Herpes simplex encephalitis treated with acyclovir: Diagnosis and long term outcome. J Neurol Neurosurg Psychiatry 1997;63:321-6.  Back to cited text no. 34
Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A 1997;94:3195-9.  Back to cited text no. 35
Borgo F, Sgaramella TM, Penello B, L'Erario R, Toso V. A componential analysis of visual object recognition deficits in patients with herpes simplex virus encephalitis. Brain Cogn 2000;43:53-6.  Back to cited text no. 36
Corstjens PL, Abrams WR, Malamud D. Detecting viruses by using salivary diagnostics. J Am Dent Assoc 2012;143:12S-8S.  Back to cited text no. 37
Yolken RH, Torrey EF. Viruses, schizophrenia, and bipolar disorder. Clin Microbiol Rev 1995;8:131-45.  Back to cited text no. 38
Srikanth S, Ravi V, Poornima KS, Shetty KT, Gangadhar BN, Janakiramaiah N. Viral antibodies in recent onset, nonorganic psychoses: Correspondence with symptomatic severity. Biol Psychiatry 1994;36:517-21.  Back to cited text no. 39
Strandberg TE, Pitkala KH, Linnavuori KH, Tilvis RS. Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases. Stroke 2003;34:2126-31.  Back to cited text no. 40
Dickerson F, Stallings C, Sullens A, Origoni A, Leister F, Krivogorsky B, et al. Association between cognitive functioning, exposure to herpes simplex virus type 1, and the COMT val158Met genetic polymorphism in adults without a psychiatric disorder. Brain Behav Immun 2008;22:1103-7.  Back to cited text no. 41
Dickerson F, Boronow JJ, Stallings C, Origoni AE, Cole SK, Yolken RH. Cognitive functioning in schizophrenia and bipolar disorder: Comparison of performance on the repeatable battery for the assessment of neuropsychological status. Psychiatry Res 2004;129:45-53.  Back to cited text no. 42
Lin WR, Wozniak MA, Cooper RJ, Wilcock GK, Itzhaki RF. Herpesviruses in brain and Alzheimer's disease. J Pathol 2002;197:395-402.  Back to cited text no. 43
Hemling N, Röyttä M, Rinne J, Pöllänen P, Broberg E, Tapio V, et al. Herpesviruses in brains in Alzheimer's and Parkinson's diseases. Ann Neurol 2003;54:267-71.  Back to cited text no. 44
Aiello AE, Haan M, Blythe L, Moore K, Gonzalez JM, Jagust W, et al. The influence of latent viral infection on rate of cognitive decline over 4 years. J Am Geriatr Soc 2006;54:1046-54.  Back to cited text no. 45
Nimgaonkar VL, Yolken RH, Wang T, Chang CC, McClain L, McDade E, et al. Temporal cognitive decline associated with exposure to infectious agents in a population-based, aging cohort. Alzheimer Dis Assoc Disord 2016;30:216-22.  Back to cited text no. 46
Dickerson FB, Boronow JJ, Stallings C, Origoni AE, Ruslanova I, Yolken RH. Association of serum antibodies to herpes simplex virus 1 with cognitive deficits in individuals with schizophrenia. Arch Gen Psychiatry 2003;60:466-72.  Back to cited text no. 47
Prasad KM, Nimgaonkar VL. Gene mapping studies for schizophrenia: How useful are they for the clinician? In: Sawa A, McInnis MG, editors. Neurogenetics of Psychiatric Disorders. New York: Taylor & Francis Group, LLC; 2007.  Back to cited text no. 48
Feinberg BB, Tan NS, Donovan PK, Loftin KC, Gonik B. Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism. J Reprod Immunol 1993;23:109-18.  Back to cited text no. 49
Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Würzner R, et al. Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol 2005;79:3675-83.  Back to cited text no. 50
Kamińska T, Wysocka A, Marmurowska-Michalowska H, Dubas-Slemp H, Kandefer-Szerszeń M. Investigation of serum cytokine levels and cytokine production in whole blood cultures of paranoid schizophrenic patients. Arch Immunol Ther Exp (Warsz) 2001;49:439-45.  Back to cited text no. 51
Kim JJ, Dayal M, Bacanu SA, Shirts BH, Wood J, Xie W, et al. Exposure to cytomegalovirus and polymorphisms in two genes on chromosome 6p21-23 as joint risk factors for schizophrenia. Am J Med Genet 2004;130B: 19.  Back to cited text no. 52
Thomas P, Bhatia T, Gauba D, Wood J, Long C, Prasad K, et al. Exposure to herpes simplex virus, type 1 and reduced cognitive function. J Psychiatr Res 2013;47:1680-5.  Back to cited text no. 53
Gur RC, Richard J, Hughett P, Calkins ME, Macy L, Bilker WB, et al. A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: Standardization and initial construct validation. J Neurosci Methods 2010;187:254-62.  Back to cited text no. 54
Thompson C, Whitley R. Neonatal herpes simplex virus infections: Where are we now? Adv Exp Med Biol 2011;697:221-30.  Back to cited text no. 55
Dickerson FB, Boronow JJ, Stallings CR, Origoni AE, Yolken RH. Reduction of symptoms by valacyclovir in cytomegalovirus-seropositive individuals with schizophrenia. Am J Psychiatry 2003;160:2234-6.  Back to cited text no. 56
Bhatia T, Wood J, Iyengar S, Narayanan SS, Beniwal RP, Prasad KM, et al. Emotion discrimination in humans: Its association with HSV-1 infection and its improvement with antiviral treatment. Schizophr Res 2018;193:161-7.  Back to cited text no. 57
Schneider F, Gur RC, Koch K, Backes V, Amunts K, Shah NJ, et al. Impairment in the specificity of emotion processing in schizophrenia. Am J Psychiatry 2006;163:442-7.  Back to cited text no. 58
Couture SM, Penn DL, Roberts DL. The functional significance of social cognition in schizophrenia: A review. Schizophr Bull 2006;32 Suppl 1:S44-63.  Back to cited text no. 59
Prasad KM, Eack SM, Keshavan MS, Yolken RH, Iyengar S, Nimgaonkar VL. Antiherpes virus-specific treatment and cognition in schizophrenia: A test-of-concept randomized double-blind placebo-controlled trial. Schizophr Bull 2013;39:857-66.  Back to cited text no. 60
Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261-76.  Back to cited text no. 61
Kennelly SP. Cognitive dysfunction: An important extrahepatic manifestation of hepatitis C infection? Postgrad Med J 2013;89:431-2.  Back to cited text no. 62
Sparkman NL, Buchanan JB, Heyen JR, Chen J, Beverly JL, Johnson RW, et al. Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J Neurosci 2006;26:10709-16.  Back to cited text no. 63
Nimgaonkar VL, Bhatia T, Mansour A, Wesesky M, Deshpande SN. Herpes simplex virus type-1 infection: associations with inflammation and cognitive aging in relation to schizophrenia. In: Khandaker G, Meyer U, Jones PJ, editors. Neuroinflammation and Schizophrenia. London: Springer; 2018.  Back to cited text no. 64

Correspondence Address:
Prof. Smita Neelkanth Deshpande
Centre of Excellence in Mental Health, PGIMER and Dr. Ram Manohar Lohia Hospital, Bangabandhu Sheikh Mujib Road, New Delhi - 110 001
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/psychiatry.IndianJPsychiatry_381_18

Rights and Permissions