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 Table of Contents    
Year : 2020  |  Volume : 62  |  Issue : 7  |  Page : 15
Young Psychiatrist Awards

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Date of Web Publication14-Jan-2020

How to cite this article:
. Young Psychiatrist Awards. Indian J Psychiatry 2020;62, Suppl S1:15

How to cite this URL:
. Young Psychiatrist Awards. Indian J Psychiatry [serial online] 2020 [cited 2021 Jun 20];62, Suppl S1:15. Available from:

   Change in reproductive profile of Schizophrenia patients over decades: a retrospective study of 2293 research participants Top

Ananya Mahapatra, Rishi Gupta, Vikas Sharma, Triptish Bhatia, Smita N Deshpande, Vishwajit L Nimgaonkar

Department of Psychiatry, Drug de-addiction and Regional Centre for Tobacco Control, India

Centre of Excellence in Mental Health, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India

Background: Western studies report patients with schizophrenia have reduced fecundity. However, there is a dearth of Indian research in this area.

Aims: To study changes in the reproductive profile of schizophrenia patients with respect to decade of birth from 1930-1999.

Materials and methods: Records of 2293 adult Schizophrenia patients (collected since 1995, as part of various research projects on schizophrenia) in whom Diagnostic Interview of Genetic Studies (DIGS) had been applied, were anonymized and extracted. Socio-demographic, clinical, and reproductive health data from the DIGS were included for secondary data analysis.

Statistical Analysis: Patient data were divided into 7 groups based on decade of birth (1930-1949 to 1990-99). Poisson regression analysis was performed using “number of living children/participant” as the dependent variable and patient characteristics as predictor variables.

Results: The mean age of the participants was 33.23 years. The mean number of living children/participants was 1.02. There was a significant difference between the 7 groups in terms of “mean number of living children/participant” (p = <0.001), highest being in 1930 - 1939 group, and least in 1990-99 group. In regression analysis, the variables “decade of birth”, “age of onset”, “number of times married”, and “number of years married” contributed significantly to the model (p< 0.001 for all variables) and explained 58% of the deviance in the dependent variable. Gender did not significantly contribute to the model (p=0.086).

Conclusion: The number of offspring in patients with schizophrenia has reduced over time. Unlike Western studies, gender was not found to have a significant effect.

Keywords: Schizophrenia, fecundity, gender, procreation

   Impairment in neurological soft signs in non-psychotic cannabis use disorder patients: Is it linked to the development of psychosis? Top

Arpit Parmar, Yatan Pal Singh Balhara, Siddharth Sarkar, Rakesh Lal

National Drug Dependence Treatment Centre & Department of Psychiatry, All India Institute of Medical Sciences, New Delhi

Title: Impairment in neurological soft signs in non-psychotic cannabis use disorder patients: Is it linked to the development of psychosis?

Background: Psychomotor functioning is known to be impaired in cannabis use disorder (CUD) patients. Cannabinoid receptors are found in abundance in multiple brain areas including the cerebellum. Neurological soft signs (NSS), which reflect dysfunction in the neural networks particularly those involving cerebellum, have rarely been studied in relation to CUD comorbid with/without psychosis. We aimed to assess and compare NSS in CUD patients with and without psychosis and healthy controls.

Materials and methods: A cross-sectional comparative study design was employed. A total of 30 right-handed male unmedicated CUD patients without any other major medical/psychiatric/substance-related illness were included in group I. Group II consisted of 30 right-handed male CUD patients with comorbid non-affective psychosis (with no other major medical/psychiatric/substance-related illness). Age, sex, and handedness matched healthy controls (n=30) were included in group III. Neurological Evaluation Scale (NES) (to assess NSS in all groups), Severity of Dependence Scale (in group I and II) and Abnormal Involuntary Movement Scale, Barnes Akathisia Rating Scale and Simpson Agnus Scale (in group II) were administered. Statistical analysis was performed using SPSS V20.0. Kruskal-Wallis H with Dune's pairwise tests were used to compare NES scores.

Results: The groups were comparable in terms of socio-demographic profile. Total NES score as well as the subdomain scores (motor coordination, sequencing of complex motor tasks, sensory integration and others) were significantly higher in group I and II as compared to group III while group I and II were largely similar in terms of mean NES scores (except sensory integration subdomain score which was higher in group II). CUD patients had particularly higher scores in the domains of motor coordination and sequencing of complex motor tasks.

Conclusions: Chronic use of cannabis may lead to cerebellar dysfunction as evident by impaired NSS. As NSS is considered to be a trait marker of psychosis, this abnormality might help to predict the future development of psychosis in vulnerable patients.

   Cognition in patients with First episode Schizophrenia : An Exploratory Study Top

Swapnajeet Sahoo

Department of Psychiatry, PGIMER, Chandigarh

Aim of the study: To compare neurocognition and social cognition in patients with First episode Schizophrenia (FES; duration of illness ≤ 5 years) during the symptomatic phase with healthy controls.

Methodology: 26 patients with FES and 26 healthy controls (age, gender, education and locality matched) were assessed on a comprehensive neurocognitive battery [Hopkins verbal learning test (HVLT), Controlled Word Association Test (COWA), Wisconsin Card Sorting Test (WCST)] and on Social cognition Rating Tools in Indian Setting (SOCRATIS) and Positive and Negative Syndrome Scale (PANSS) during the symptomatic phase.

Results: Compared to healthy controls, patients with FES had significantly poor verbal learning, verbal memory, verbal fluency, executive functions and poor social cognitions, more so in the domains of first order theory of mind, second order theory of mind, faux paus composite index, social perception index and non-social perception index. Except a significant association between the second order theory of mind domain of social cognition with psychopathology score and verbal fluency test of neurocognition, no other significant association was found between any of the domains of social cognitions, neurocognition and clinical variables in patients with FES.

Conclusions: The present study suggests that patients with FES have significant neurocognitive and social cognitive deficits during the symptomatic phase of illness. Appropriate and early intervention needs to be planned to address neurocognitive and social cognitive deficits in patients with FES.

Key words: Neurocognition, social cognition, first episode schizophrenia

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