Year : 1998  |  Volume : 40  |  Issue : 1  |  Page : 60--66

Active Platelet 5-HT Uptake in Depressives Treated with Impramine and ECT


PK Dalal1, Narottam Lal3, JK Trivedi3, PK Seth2, AK Agarwal3, Abdul Khalid4 
1 Associate Professor, Department Psychiatry, K.G.'s Medical College, Lucknow, India
2 Director, Industrial Toxicology Research Centre, Lucknow, India
3 Scientist, Industrial Toxicology Research Centre, Lucknow, India
4 Ex- Senior Resident, Department Psychiatry, K.G.'s Medical College, Lucknow, India

Correspondence Address:
P K Dalal
Associate Professor, Department Psychiatry, K.G.SQs Medical College, Lucknow
India

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.


How to cite this article:
Dalal P K, Lal N, Trivedi J K, Seth P K, Agarwal A K, Khalid A. Active Platelet 5-HT Uptake in Depressives Treated with Impramine and ECT.Indian J Psychiatry 1998;40:60-66


How to cite this URL:
Dalal P K, Lal N, Trivedi J K, Seth P K, Agarwal A K, Khalid A. Active Platelet 5-HT Uptake in Depressives Treated with Impramine and ECT. Indian J Psychiatry [serial online] 1998 [cited 2021 Sep 19 ];40:60-66
Available from: https://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=1998;volume=40;issue=1;spage=60;epage=66;aulast=Dalal;type=0