Year : 2000  |  Volume : 42  |  Issue : 3  |  Page : 295--301

A Double-Blind, Placebo-Controlled Evaluation of the Anxiolytic Efficacy ff an Ethanolic Extract of Withania Somnifera


Chittaranjan Andrade1, Anitha Aswath2, SK Chaturvedi3, M Srinivasa4, R Raguram3 
1 Additional Professor & Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India
2 Research Assistant, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India
3 Additional Professor, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India
4 Chief Consultant, Spandana Psychiatric Hospital, Bangalore-560010, India

Correspondence Address:
Chittaranjan Andrade
Additional Professor & Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029
India

A double-blind, placebo-controlled study was conducted to evaluate the efficacy an ethanolic extract of Aswagandha (Withania somnifera), in patients with ICD-10 anxiety disorders. The sample comprised 39 subjects, of whom 20 received the drug and 19 received placebo. The two groups were sociodemographically and clinically similar at baseline. At 2 and 6 weeks follow-up, data from approximately 85% of patients in each group were available for analysis. Statistical trends favouring the drug were observed at both time points. At 6 weeks, significantly more patients met a priori response criteria in the drug group (88.2%) as compared with the placebo group (50%). The drug was well-tolerated and did not occasion more adverse effects than did placebo. It is concluded that this ethanolic extract of Withania somnifera has useful anxiolytic potential and merits further investigation.


How to cite this article:
Andrade C, Aswath A, Chaturvedi S K, Srinivasa M, Raguram R. A Double-Blind, Placebo-Controlled Evaluation of the Anxiolytic Efficacy ff an Ethanolic Extract of Withania Somnifera.Indian J Psychiatry 2000;42:295-301


How to cite this URL:
Andrade C, Aswath A, Chaturvedi S K, Srinivasa M, Raguram R. A Double-Blind, Placebo-Controlled Evaluation of the Anxiolytic Efficacy ff an Ethanolic Extract of Withania Somnifera. Indian J Psychiatry [serial online] 2000 [cited 2021 Oct 22 ];42:295-301
Available from: https://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2000;volume=42;issue=3;spage=295;epage=301;aulast=Andrade;type=0