Year : 2020  |  Volume : 62  |  Issue : 4  |  Page : 413--417

Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population


Zhilin Luan1, Wenhua Ming1, Xiaoxiao Huo1, Jingwei Yu2, Bing Wang3, Yang Sun4 
1 Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China
2 Department of Biology, Guangdong Pharmaceutical University, Guangzhou, China
3 Advanced Institute for Medical Sciences, Dalian Medical University; Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China
4 Department of Psychiatry, Dalian Seventh People's Hospital, Dalian, China

Correspondence Address:
Dr. Zhilin Luan
Advanced Institute for Medical Sciences, Dalian Medical University, 9 W, S. Lvshun Blvd, Dalian, 116044
China

Background: GAP43, a membrane phosphoprotein with high expression level in the developing brains, plays an important role in higher integrative functions of the brain. Materials and Methods: To explore the association of GAP43 with schizophrenia, 11 single-nucleotide polymorphisms (SNPs) were examined in a Northeast Chinese Han sample set consisting of 741 schizophrenia patients and 1330 healthy controls. Results: The results showed that three SNPs were associated with schizophrenia (rs2028248, rs6790048, and rs2164930). Haplotype analysis also revealed a significant association of a strong linkage disequilibrium block (rs2164930-rs11926976-rs16823991) with schizophrenia. Conclusion: The current findings suggested that the human GAP43 gene may be a susceptibility gene for schizophrenia.


How to cite this article:
Luan Z, Ming W, Huo X, Yu J, Wang B, Sun Y. Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population.Indian J Psychiatry 2020;62:413-417


How to cite this URL:
Luan Z, Ming W, Huo X, Yu J, Wang B, Sun Y. Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population. Indian J Psychiatry [serial online] 2020 [cited 2021 Jul 24 ];62:413-417
Available from: https://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2020;volume=62;issue=4;spage=413;epage=417;aulast=Luan;type=0