Indian Journal of PsychiatryIndian Journal of Psychiatry
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   1991| April-June  | Volume 33 | Issue 2  
    Online since February 20, 2009

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Pharmacokinetics of Nitroxazepine in Depressed Patients
AD Bhatt, AM Nandkarni, LP Shah, R Bakshi, KJ Doshi, SJ Shah, KC Gupta, SC Bhatia, AB Vaidya
April-June 1991, 33(2):108-112
A pharmacokinetic study was done on 10 depressed patients (DSM-III-R 296.3). The patients were treated with Sintamil (R) (nitroxazepine HCl) with titrated dose from 75 mg to 225 mg for 6 weeks. Plasma levels of nitroxazepine (Sintamil (R)) and its metabolites desmethyl (D), N-oxide (N-O) and carboxylic acid (c) were estimated. Anti-depressant efficacy was judged by reduction in Hamilton Rating Depression Scale (HDRS) scores, and tolerability was monitored by reports of unwanted effects. The overall reduction in HDRS score was about 50% by 6 weeks. The plasma levels of nitroxazepin (ng/ral) showed a rise from a mean ( +SEM) level. 47.0 4-7.3 on day 1 (dose 75 mg) to 129.84-24.6 on day 7 (dose 150 mg) (p<0.01) and remained steady till day 21. There were large interindividual variations. The metabolites followed a similar pattern. The HDRS score showed a steady reduction between day 14 and 42 when the levels of nitroxizepine and des-methyl metabolites were maintained between 176.5 ng/ml to 251 ng/ml.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  854 65 -
Meditation from a Mental Health Prospective
K Bhaskaran
April-June 1991, 33(2):87-94
The term ' 'Meditation" is defined and the aims of meditation-practice are outlined. The physiological and psychological correlates of meditation, as found in different studies, are described. The need for an integrated approach to the study of consciousness is emphasized. The clinical applications of meditation practice are spelt out. Areas of further research are indicated.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  676 148 -
Catatonia and Hyponatremia : A Case Report
S Haque Nizamie, Rakesh Khanna, LN Sharma
April-June 1991, 33(2):118-122
We report a case of recurrent mania who developed catatonia and was found to be markedly hyponatraemia. The catatonic symptoms showed rapid resolution following correction of hyponatraemia suggesting a causal link between the two. It is suggested that the estimation of serum electrolyte levels should be an important part of the evaluation of cases of catatonia.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  727 90 -
A Double-Blind Evaluation of Alprazolam and Imipramine in the Treatment of Major Depression
RS Murthy, Somanath Chatterjee, TG Sriram, LP Shah, Rajesh Parikh, S Elavia, GC Munjal, Ravi Nehru, V Ramachandran, G Nirmala, KS Raghavan, V Kumar
April-June 1991, 33(2):104-107
This report describes the results of a multicentre collaborative study comparing the safety and efficacy of alprazolam with imipramine in patients suffering from major depressive disorder. Two hundred and eight patients diagnosed as major depression as per DSM-III criteria were randomly allocated to alprazolam (N= 105) or imipramine (N = 103) in a double-blind fashion. Detailed assessments were carried out for a period of six weeks. Results revealed that alprazolam was as effective as imipramine as an antidepressant. Side effects were less frequently reported with alprazolam.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  731 64 -
A Clinical and Behavioural Study of HIV Infected Subjects-A Comparison with STD Subjects
A Venkoba Rao, R Swaminathan, MK Venkataram, S Ramajayam, Rashmi Parhee, Narendra Kumar, Usha K Luthra
April-June 1991, 33(2):95-103
Eightyfive HIV seropositive subjects (M: 42;F:43) were compared with an equal number STD subjects negative for HIV. They formed 1.6% of the total number (N =5287) screened in the STD OP. Heterosexual transmission was predominant. A significantly higher promiscuity and a larger number of sex partners and contacts were observed in the female but not the male HIV subjects. The ages at first coital experience were similar in both the groups. There was no difference in the occurrence of either STDs or psychiatric illness at index examination between the two groups. The symptom profile of psychiatric illness in the HIV subjects did not differ from that of the controls. The HIV subjects had more of physical diagnoses than the controls. The psychological responses to the 'disclosure' of seropositivity were noted. The closeness of HIV and STD groups on many factors and its implication for management and health education are commented upon.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  673 86 -
Autism in Tuberous Sclerosis
Rakesh Khanna, Mamta Sood
April-June 1991, 33(2):113-117
A case of Tuberous Sclerosis with infantile autism, misdiagnosed as mental retardation with seizure disorder is being discussed in light of the implication of the misdiagnosis.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  591 73 -
Mental Health Programme : Need for Redemption
AK Agarwal
April-June 1991, 33(2):85-86
Full text not available  [PDF]  [PubMed]
  367 54 -
Report Of The Hon.General Secretary, Indian Psychiatric Society For The Year 1990

April-June 1991, 33(2):123-125
Full text not available  [PDF]
  315 47 -